Evidence map›Paper›PMID 40640964›Full record

ArticleParasites & vectors2025

Clonorchis sinensis infection remodels chromatin accessibility in hepatocellular carcinoma.

Weilong Yang, Caibiao Wei, Junxian Chen, Qiumei Lin, Yuling Qin, Taijun Huang, Xueling Deng, Mulin Jun Li, Zeli Tang, Min Fang

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PubMed Full text at PMC Publisher
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Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Editorial: Parasite-induced liver diseases, volume II.Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weilong Yang *Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Caibiao Wei *Department of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China.
Junxian Chen *Department of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China.
Qiumei LinDepartment of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China.
Yuling QinDepartment of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China.
Taijun HuangDepartment of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China.
Xueling DengDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, China.
Mulin Jun LiGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. mulin@tmu.edu.cn.
Zeli TangDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, China. Tangzeli_team99@163.com.
Min FangDepartment of Clinical Laboratory, Guangxi Medical University Cancer Hospital, Nanning, 530021, Guangxi, China. fangmin@sr.gxmu.edu.cn.

Funding

National Science Foundation of China 82360410National Science Foundation of Guangxi 2024GXNSFAA010212Promotion Ability Project of Young Teachers in Guangxi Universities 2020KY03018the Self-raised Scientific Research Fund of the Ministry of Health of Guangxi Province Z20211408
6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is a major global health concern, accounting for a significant proportion of liver cancer cases and related deaths. Clonorchis sinensis (C. sinensis) infection, a recognized carcinogen, has been implicated in the progression of liver diseases, including HCC. However, the precise epigenetic mechanisms underlying C. sinensis-associated HCC remain to be elucidated.

methodsTo investigate the role of chromatin accessibility in C. sinensis-related HCC progression, we performed an assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) analyses of C. sinensis-infected (C. sinensis

resultsATAC-seq analysis revealed 9,396 differentially accessible regions (DARs) in C. sinensis

conclusionsOur study demonstrates that C. sinensis infection remodels chromatin accessibility and may contribute to HCC progression. Our work offers valuable insights into the pathogenesis of HCC in the context of parasitic infection and lays the groundwork for future biomarker and therapeutic target discovery.

Indexed as

Carcinoma, HepatocellularChromatinChromatin Assembly and DisassemblyClonorchiasisClonorchis sinensisLiver NeoplasmsAnimalsCell Line, TumorCell MovementEpigenesis, GeneticHumansChromatinChromatin accessibilityClonorchis sinensisHepatocellular carcinomaTranscription factorTumor progression

Identifiers

PMID40640964
PMCPMC12247385

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.