Evidence map›Paper›PMID 40640900›Full record

ArticleThrombosis journal2025

Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective.

Galila Mokhtar, Ashraf Abdelbaky, Amira Adly, Dina Ezzat, Hanafy Hafez, Hoda Hassab, Ilham Youssry, Iman Ragab, Laila M Sherief, Marwa Zakaria and 15 more

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Article in Thrombosis journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Galila MokhtarPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo, Egypt.
Ashraf AbdelbakyPediatrics and Pediatric Allergy and Immunology, Ain Shams University, Cairo, Egypt.
Amira AdlyPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo, Egypt.
Dina EzzatPediatric Hematology Unit, Pediatric Department, Beni-Suef University, Beni-Suef, Egypt.
Hanafy HafezNational Cancer Institute, Cairo University, Cairo, Egypt.
Hoda HassabPediatric Hematology and Oncology Unit, Pediatric Department, Alexandria University, Alexandria, Egypt.
Ilham YoussryPediatric Hematology Department, Cairo University, Cairo, Egypt.
Iman RagabPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo, Egypt.
Laila M SheriefPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig University, Zagazig, Egypt.
Marwa ZakariaPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig University, Zagazig, Egypt.
Mervat HeshamPediatric Hematology and Oncology Unit, Pediatric Department, Zagazig University, Zagazig, Egypt.
Mervat MansourPediatric Intensive Care, Ain Shams University, Cairo, Egypt.
Naglaa ShaheenPediatric Hematology Department, Atfal Masr Health Insurance Hospital, Cairo, Egypt.
Tarek OmarPediatrics and Pediatric Neurology Department, Alexandria University, Alexandria, Egypt.
Rasha Abdel-Raouf Abdelaziz AfifiPediatric Hematology Department, Cairo University, Cairo, Egypt.
Sara MakkeyahPediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo, Egypt.
Sonia AdolfPediatrics Hematology Department, Institute of Medical Research and Clinical Studies, National Research Center, Giza, Egypt.
Yasser AmerAlexandria Center for Evidence-Based Clinical Practice Guidelines, Alexandria University, Alexandria, Egypt.
Heba HusseinPeriodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Hanan IbrahimPediatric Intensive Care, Ain Shams University, Cairo, Egypt.
Khaled SalamaPediatric Hematology and Oncology Unit, Pediatric Department, Alexandria University, Alexandria, Egypt.
Ahmad DarwishPediatric Hematology and Oncology Unit, Pediatric Department, Mansoura University, Mansoura, Egypt.
Leonardo R BrandaoThe Hospital for Sick Children, University of Toronto, Toronto, Canada.
Ivan FlorezDepartment of Pediatrics, University of Antioquia, Medellín, Colombia.
Gehan Lotfy Abdel Hakeem KhalifaPediatric Hematology and Oncology Unit, Pediatric Department, Minia University, El Minya, Egypt. gehan.khalifa@mu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombosis is a major pediatric health problem with a spectrum of etiologies, clinical presentations, and morbidities. Establishing the diagnosis and treatment of pediatric thrombosis with different site-related presentations may be challenging. This article adapts the high-quality Clinical Practice Guidelines (CPGs) for pediatric thrombosis management to suit the Egyptian healthcare context.

methodsThe adapted ADAPTE methodology was used to identify the high-quality CPGs published between 2012 and 2023. An expert panel screened, reviewed, and assessed the CPGs and formulated the adapted consensus recommendations based on the best available evidence.

resultsThe final CPG document provides consensus recommendations and implementation tools for managing thrombosis with different etiologies in children and adolescents in Egypt. There is no evidence to support strong recommendations for various management approaches.

conclusionsIn general, a complete clinical and radiological assessment and some laboratory tests are indicated at the initial diagnosis to confirm a thrombotic disorder and to further choose the type of workup required. Future research should report the outcome of this adapted guideline and include cost-analysis evaluations.

Indexed as

ManagementPediatricThrombosis

Identifiers

PMID40640900
PMCPMC12247309

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.