ArticleBMC chemistry2025
Synthesis, characterization, computational and dyeing behavior of Cu(II) and Zn(II) metal complexes derived from azo-Schiff bases containing phenol derivatives.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study discusses the synthesis, characterization, and applications of two novel azo-Schiff bases, HL1 and HL2, derived from HL, 4-((3-formyl-4-hydroxyphenyl)diazenyl)benzenesulfonamide with o-aminophenol and o-amino-thiophenol, respectively, and their Cu(II) and Zn(II) complexes. Stability, dyeing, biological activity, and computational investigations with experimental data are examined. HL1, HL2 and their metal complexes were fully characterized utilizing different physicochemical techniques, such as UV-Vis, FTIR, mass spectra, thermal analysis (TGA, DTG and DTA), as well as EPR, molar conductivity measurements for metal complexes. The experimental findings showed that the metals were ligated to the azo-Schiff bases, HL1 and HL2 via the azomethine-N and phenolic-O or thiolato-S, respectively. The properties of the compounds as polyester fabric dyes were examined. They were evaluated for color fastness to washing, rubbing, and perspiration using ISO 105-C02:1989, X12:1987, and E04:1989. The colored materials’ superior intra-fiber diffusion inside the substrate may explain their exceptional washing and rubbing and perspiration fastness. In vitro antimicrobial efficiency of all products was explored against a panel of pathogenic bacteria, including Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria Escherichia coli and Proteus vulgaris, and pathogenic fungi Aspergillus flavus and Candida albicans, compared to Gentamycin and Ketoconazole as standards. Additionally, the cytotoxicity of developed compounds in one human cell line, lung carcinoma (A-549), was examined, demonstrating how chelation and molecular structure can affect anticancer activity. Compared to Ascorbic acid, their antioxidant activities were evaluated, and their ability to reduce DPPH radical was affected by molecular composition and structure. For free ligands, HL1 > HL > HL2 decreased power. For metal complexes, [Cu(L1)₂]0.5 H₂O was more potent than [Zn(L1)₂].2H₂O, but [Zn(L2)₂].2H₂O >[Cu(L2)₂]0.3 H₂O, as antioxidant. The applied computational studies and molecular docking on the proposed structures of the complexes were in good agreement with the experimental results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.