ArticleJournal of orthopaedic surgery and research2025
Vitamin D deficiency and adverse body composition in adolescents.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Interaction between vitamin D and the growth hormone/insulin-like growth factor 1 axis in children: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- DXA-Derived Total Body Fat Percentage and Serum 25(OH)D in Overweight and Obese Children: A Cross-Sectional Study.Nutrients · 2026Article
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Authors and funding
3 authors.
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Abstract
backgroundVitamin D deficiency is a global public health concern, particularly among adolescents. While its skeletal effects are well-established, evidence on its extraskeletal roles in muscle and adipose tissue during this critical developmental period remains limited, especially using direct body composition measures.
methodsWe analyzed 3,648 participants aged 12-19 years from NHANES data (2011-2018), stratifying vitamin D status as deficiency, insufficiency, or sufficiency. Multivariable linear regression models evaluated associations with appendicular lean mass index (ALMI), visceral adipose tissue area (VATA), and total bone mineral density (BMD). Subgroup analyses explored age, sex, and racial/ethnic variations.
resultsVitamin D deficiency/insufficiency affected 40.1% of participants. Higher serum vitamin D status correlated with positive body composition: lower VATA (β = -0.092, 95% CI: -0.124 to -0.061), and higher ALMI (β = 0.005, 95% CI: 0.004 to 0.006) and BMD (β = 0.0008, 95% CI: 0.0006 to 0.0010). Subgroup analyses revealed stronger ALMI associations in older boys and Mexican Americans, while VATA reductions were most pronounced in younger girls. BMD benefits were consistent across subgroups.
conclusionsVitamin D deficiency is prevalent among adolescents and independently associated with unfavorable body composition, modulated by demographic factors. These findings highlight the need for targeted interventions to optimize musculoskeletal and metabolic health during this developmental window.
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