ArticleItalian journal of pediatrics2025
Shifting epidemic trends and severity in pediatric Mycoplasma pneumoniae infections in the post-COVID-19 era.
Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Epidemic Pattern Changes in Influenza A and B and Mycoplasma pneumoniae Pediatric Respiratory Infections During and After the COVID-19 Pandemic Restrictions in Northwest China.Current microbiology · 2026Article
- Changes in Epidemiological Characteristics in Children withJournal of clinical medicine · 2026Article
- Article
- Early prediction of plastic bronchitis in pediatric patients withFrontiers in cellular and infection microbiology · 2026Article
- Ecological reshaping of pediatric respiratory pathogen profiles after COVID-19-related non-pharmaceutical interventions were lifted: a 5-year interrupted time-series study.Frontiers in pediatrics · 2026Article
- Post-pandemic resurgence and collapse ofFrontiers in public health · 2026Article
- Direct hospitalization costs of children withFrontiers in public health · 2026Article
- A retrospective study on pediatric pertussis: comprehensive evaluation of symptoms, laboratory indicators, and diagnostic efficacy of case definitions.Frontiers in cellular and infection microbiology · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundWhile non-pharmaceutical interventions (NPIs) implemented for COVID-19 have been shown to affect the epidemiology of respiratory pathogens, the impact of China's prolonged NPIs on Mycoplasma pneumoniae (MP) remains unclear. This study aimed to analyze the MP test positivity rates, as well as assessing disease severity in pediatric cases before and after the three-year NPI period.
methodsWe conducted a repeated cross-sectional study using electronic health records from Tongji Hospital, Wuhan, China. Children aged ≤ 14 years who tested nasopharyngeal/oropharyngeal swabs for MP using real-time polymerase chain reaction from January 2023 to June 2024 were included, along with data from four pre-intervention years (2016-2019). Primary outcomes included monthly MP test positivity rates and severity outcomes. To assess changes in test positivity, segmented quasi-Poisson regression models were used to calculate prevalence ratio (PR) and 95% confidence interval (CI). Linear regression models were employed to evaluate changes in continuous severity parameters, while log-binomial models were used to assess the PR for dichotomous severity outcomes.
resultsAmong 56,232 pediatric patients, 10,476 (18.63%) tested positive for MP. The post-intervention MP resurgence peaked later, with an average monthly positivity rate significantly exceeding predicted values (18.77% vs. 10.87%; PR = 1.69, 95% CI: 1.33, 2.16). After adjusting for age and sex, children hospitalized with MP infection in the post-intervention period exhibited higher white blood cell counts (10^
conclusionsA significant increase in MP infections and disease severity was observed following the relaxation of NPIs in late 2022, warranting further investigation into the long-term effects of NPIs on MP infections in children.
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