Evidence map›Paper›PMID 40640816›Full record

ArticleVirology journal2025

Neonatal mouse model reveals pathogenesis of Shanxi Tick Virus 2 isolated from Haemaphysalis longicornis.

Fan Li, Reichen Wang, Bangshuai Zhang, Guangjun Jin, Jingdong Song, Weimin Gou, Changyuan Sun, Qikai Yin, De Li, Kai Nie and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fan Li *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
Reichen Wang *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
Bangshuai ZhangHunchun Center for Disease Control and Prevention, Yianbian, Jilin, 133300, People's Republic of China.
Guangjun JinHunchun Center for Disease Control and Prevention, Yianbian, Jilin, 133300, People's Republic of China.
Jingdong SongNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
Weimin GouYianbian Center for Disease Control and Prevention, Yianbian, Jilin, 133000, People's Republic of China.
Changyuan SunYianbian Center for Disease Control and Prevention, Yianbian, Jilin, 133000, People's Republic of China.
Qikai YinNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
De LiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
Kai NieNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
Qianqian CuiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
Shihong FuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
Songtao XuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China.
Qiang WeiChinese Center for Disease Control and Prevention, Beijing, 102206, China.
Huanyu WangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, 102206, China. wanghy@ivdc.chinacdc.cn.

Funding

Beijing Natural Science Foundation L232069
6 · The paper itself

Abstract

Shanxi Tick Virus 2(SXTV2), a Tamdy group member of Orthonairovirus genus, Nairoviridae family, was initially identified through Next Generation Sequencing, with its pathogenicity and risk profile remaining unclear. This study reports the first successful isolation of SXTV2 from Haemaphysalis longicornis ticks collected from Hunchun City, China-a tri-border region between China, Russia, and North Korea. The isolated SXTV2 strain replicated and produced cytopathic effects in both Vero (primate) and SW-13 (human) cell lines. Electron microscopy revealed that SXTV2 particles are enveloped, surface-spiked, pleomorphic, and approximately 100 nm in diameter. Experimental inoculation in neonatal mice led to significant weight loss, liver injury and 100% mortality. In conclusion, this study marks the first successful isolation of the SXTV2 strain and exploring the animal model for member of Tamdy group orthonairovirus. These findings suggest the need for enhanced surveillance of SXTV2 zoonotic exposure and disease epidemic risks.

Indexed as

IxodidaeNairovirusAnimalsAnimals, NewbornCell LineChinaChlorocebus aethiopsCytopathogenic Effect, ViralDisease Models, AnimalHaemaphysalis longicornisHumansMiceVero CellsVirus ReplicationFirst isolationNeonatal mouse lethalityOrthonairovirusShanxi Tick Virus 2

Identifiers

PMID40640816
PMCPMC12243325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.