Observational studyBMC cancer2025
Utility of the prostest to predict and monitor response to chemotherapy in metastatic Castration-Resistant prostate cancer: A prospective pilot study.
Observational study in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06872619 (A Registry for Prostate Cancers), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Registry for Prostate Cancers
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastatic castration-resistant prostate cancer (mCRPC) treatment has advanced with therapies such as androgen receptor pathway inhibitors (ARPIs), taxane chemotherapies like docetaxel, and novel agents like 177Lu-PSMA. However, predicting patient responses and sequencing therapies remain critical unmet needs. This study investigated whether the PROSTest, a molecular assay analyzing prostate cancer-specific transcripts, could predict treatment response or prognosis in mCRPC patients receiving docetaxel, compared to changes in prostate-specific antigen (PSA) levels.
methodsNineteen patients with mCRPC were treated with a median of 10 docetaxel cycles. PROSTest, which measures tumor-related signaling pathways, was analyzed via qPCR, while PSA levels were determined using standard clinical assays. PSA and PROSTest scores were measured at baseline and after one treatment cycle. PROSTest, which evaluates tumor-related signaling pathways, was analyzed via qPCR, and prostate-specific antigen (PSA) levels were measured using standard clinical assays. Responses were categorized per Prostate Cancer Working Group 3-criteria. Associations between biomarker changes, progression-free survival (PFS), and overall survival (OS) were evaluated using Kaplan-Meier survival analysis and hazard ratios (HRs).
resultsBaseline PSA and PROSTest scores did not predict response or survival. However, early changes in both biomarkers after one treatment cycle significantly correlated with PSA-PFS. PROSTest changes demonstrated a stronger association with PFS (HR: 0.04) compared to PSA (HR: 0.2). Early changes in PROSTest were also significantly (p = 0.03, AUC = 0.81 ± 0.14) associated with OS in contrast to PSA changes.
conclusionsThis pilot study suggests that PROSTest may offer superior predictive and prognostic value compared to PSA in mCRPC patients undergoing docetaxel therapy. Larger, multicenter studies are needed to confirm these findings and validate the assay’s clinical integration.
trial registrationNCT06872619.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.