Trial reportBMC pediatrics2025
Effects of transcranial direct current stimulation and mirror therapy on mental health and dopamine level among spastic quadriplegic cerebral palsy children.
Trial report in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundCerebral palsy (CP) is a neurological condition affecting a child's motor development, potentially disturbing their mental health, which is an emerging challenge for rehabilitation. Transcranial direct current stimulation (tDCS) and mirror therapy (MT) are novel neurorehabilitation techniques that enhance mental health and motor development.
methodsA double-blinded randomized clinical trial was conducted on 105 children with spastic quadriplegic CP between the ages of three to seven years. The study was conducted in the Physical Therapy Center of Ghurki Hospital, Lahore. The patients were divided into three groups of 35 patients: Group A (tDCS + MT + Routine Physical Therapy (RPT)), Group B (MT + RPT), and Group C (tDCS + RPT) through Randomized Allocation Software Version 1.0. Patients underwent 10 sessions of tDCS and MT, each lasting for 15 min per side (right and left), along with 20 min of RPT five days a week, which continued for the next ten weeks on follow-up. The mental health of CP children from different age ranges was assessed by the Strengths and Difficulties Questionnaire (SDQ), a brief and accessible screening tool covering a child's emotional symptoms, conduct problems, hyperactivity/inattention, peer relationship problems, and social behavior. Designed for teachers and parents, the self-report versions have a reliability of 0.80. Dopamine was measured using a plasma lab test to explore its potential relationship with changes in mental health status following the intervention. Assessment was conducted at baseline, after two weeks, and again after ten weeks of follow-up. The data was analyzed via SPSS version 26.0.
resultsThe results revealed a significant change in the mean score of Strengths and Difficulties Questionnaires (SDQ) after ten weeks (P = 0.004) and in dopamine levels after two weeks (P < 0.001). Additionally, group comparison revealed statistically significant changes in both SDQ scores (P = 0.001 for group A and P = 0.002 for group C) and dopamine levels (P = 0.000 for group A and P = 0.002 for group C) but not group B at the specified time intervals.
conclusionThe combined treatment of tDCS and MT improved mental health and increased dopamine levels more than either treatment alone. Dopamine levels increased initially but decreased during follow-up.
trial registrationThe trial was registered in the Iranian Registry of Clinical Trials (IRCT20231227060542N1) on 26-01-2024. https://irct.behdasht.gov.ir/ .
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