ArticleBMC genomics2025
K1 Klebsiella pneumoniae is more conserved than K2 for both virulence plasmid and chromosome.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A novel phage preparation capable of simultaneously inhibiting both K1 and K2 serotypes ofApplied and environmental microbiology · 2026Article
- Pathogenic diversity ofFrontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo illustrate the differences between K1 and K2 Klebsiella pneumoniae strains.
methodsTotally 68 K1 and 99 K2 K. pneumoniae strains from GenBank were analyzed for virulence genes, sequence types (STs), restriction-modification (R-M) systems, and clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems. Phylogenetic trees of the virulence plasmids and chromosomes in the strains were built using kSNP4.
resultsVirulence genes peg-344, allS, p-rmpA, p-rmpA2, c-rmpA, iroN, and iucA were more prevalent in K1 strains than K2. K1 strains were categorized into 7 STs with 79.41% being ST23 while K2 strains were categorized into 14 STs with 38.38% being ST14. K1 strains showed higher rates of CRISPR-Cas systems than K2 while lower rates of Type I and II R-M systems were found in K1 strains than K2. More rates of virulence plasmids (52/68 vs. 24/99) were found in K1 strains than K2. Based upon the phylogenetic tree of virulence plasmids, 46 in K1 strains belonged to the same clade while 11 and 7 virulence plasmids in K2 strains constituted the 2 major clades. For the chromosomes, 61 K1 strains belonged to the same clade while 99 K2 strains could be categorized into 4 major clades.
conclusionsK1 K. pneumoniae strains are more conserved than K2 for both virulence plasmids and chromosomes. K1 strains are deficient in R-M systems but rich in CRISPR-Cas, which is contrary to K2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.