ArticleBMC gastroenterology2025
Prognostic value of the international normalized ratio to albumin ratio in acute pancreatitis: insights from MIMIC-IV database.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Prognostic Significance of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in Cancer Patients with Complication of Sepsis: A Retrospectively Cohort Study.Shock (Augusta, Ga.) · 2026Article
- Article
- Research Topics and Trends in MIMIC-IV: A Large ICU Database Relevant for Critical Care Nursing.Nursing in critical care · 2026Review
- Calculated serum osmolarity distribution in critically ill patients with acute pancreatitis: a retrospective cohort study.BMC gastroenterology · 2026Article
- Creatinine-to-albumin ratio for early ICU-course (first 24 hours) risk stratification of mortality in critically ill patients with gastrointestinal bleeding: A retrospective cohort study.Science progress · 2026Article
- Relationship Between International Normalized Ratio to Albumin Ratio and Mortality in Critically Ill Patients With Myocardial Infarction.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
6 authors.
Funding
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Abstract
backgroundWhile the prognostic value of the international normalized ratio - to - albumin ratio (PTAR) has been established in several diseases, its predictive value in acute pancreatitis (AP) mortality remains uncertain. This study aimed to investigate the association between PTAR and survival outcomes in AP patients.
methodsInitial screening using univariate and multivariate regression analysis identified significant prognostic variables. Survival distributions according to different PTAR levels were compared using the Kaplan - Meier (K - M) method. Receiver operating characteristic (ROC) curves were used to evaluate its discriminative performance in terms of sensitivity and specificity. Nonlinear relationships of PTAR with survival outcomes were assessed using restricted cubic spline (RCS) regression, and stratified cohort examinations were conducted to address potential confounding effects.
resultA total of 459 patients were enrolled in this study. They were categorized into two groups based on their PTAR scores: high - risk (≥ 0.58) and low - risk (< 0.58). A significant association was found between elevated PTAR and increased mortality at various time points, such as 7, 14, 21, 28, 90, and 365 days (P < 0.05). The Cox proportional hazards model revealed a significant independent association between higher PTAR and mortality, with hazard ratios consistently significant across all time points (P < 0.05). Patients in the high - risk group showed persistently higher mortality rates (P < 0.05 for all comparative time points). ROC analysis showed similar predictive performance of PTAR and the SOFA score for mortality. No statistically significant interaction between PTAR status and treatment effects was observed (p > 0.05).
conclusionPTAR has shown significant associations with clinical outcomes in patients with AP.
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