Evidence map›Paper›PMID 40640637›Full record

ArticleCognitive, affective & behavioral neuroscience2025

Twin differences in the Minnesota Trust Game relate to neural mechanisms of suspiciousness.

Rebecca Kazinka, Anita N D Kwashie, Danielle N Pratt, Iris Vilares, William G Iacono, Sylia Wilson, Angus W MacDonald

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cognitive, affective & behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rebecca KazinkaPsychiatry Department, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0003-1414-8164
Anita N D KwashiePsychology Department, University of Minnesota, Minneapolis, MN, USA.
Danielle N PrattPsychology Department, Northwestern University, Evanston, IL, USA.
Iris VilaresPsychology Department, University of Minnesota, Minneapolis, MN, USA.
William G IaconoPsychology Department, University of Minnesota, Minneapolis, MN, USA.
Sylia WilsonInstitute for Child Development, University of Minnesota, Minneapolis, MN, USA.
Angus W MacDonaldPsychology Department, University of Minnesota, Minneapolis, MN, USA. angus@umn.edu.

Funding

Twin Family Study of Vulnerability to Substance AbuseR37DA005147 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2009 to 2018
$6.4M
TWIN STUDY OF ADHD, CD, AND SUBSTANCE ABUSER01DA013240 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G. · 2000 to 2010
$5.0M
Adult consequences of youth substance use: Twin study enriched for SUD riskR01DA036216 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2013 to 2017
$3.2M
Minnesota Neuroimaging Postdoctoral Training GrantT32EB031512 · NIBIB · UNIVERSITY OF MINNESOTA · PI NETOFF, THEODEN I, UGURBIL, KAMIL · 2021 to 2025
$1.1M
Brain Deviation Preceding Substance Use: An Offspring of Co-Twin Control StudyK01DA037280 · NIDA · UNIVERSITY OF MINNESOTA · PI WILSON, SYLIA · 2015 to 2019
$764k
Persecution in RDoC: Spite Sensitivity and Frontal DysconnectivityR21MH112918 · NIMH · UNIVERSITY OF MINNESOTA · PI MACDONALD, ANGUS W · 2017 to 2018
$422k
Circuit plasticity regulation of fear memory expressionF32MH115688 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CUMMINGS, KIRSTIE ALYSSA · 2018 to 2019
$79k
NIBIB NIH HHS T32 EB031512NIBIB NIH HHS T32-EB031512NIDA NIH HHS K01 DA037280NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA036216NIDA NIH HHS R37 DA005147NIH HHS K01DA037280NIH HHS R01DA013240NIH HHS R01DA036216NIH HHS R37DA005147NIMH NIH HHS F32 MH115688NIMH NIH HHS R21 MH112918NIMH NIH HHS R21MH112918NIMH NIH HHS T32-MH115688
6 · The paper itself

Abstract

Spite sensitivity, or the fear that a person is willing to intentionally take a loss to ensure that another person will as well, may be a key component in understanding persecutory ideation (the belief that others want to harm you). We implemented a co-twin control design to examine potentially causal relationships among persecutory ideation, spite sensitivity, and neural activity and connectivity. Sixty-nine participants (23 monozygotic twin pairs and an additional 23 unpaired monozygotic twins) completed the Minnesota Trust Game-a social decision-making game played asynchronously with an anonymous partner that targets spite sensitivity by varying the incentives of the partner. Participants with more self-reported persecutory ideation (relative to those with lower persecutory ideation) trusted less even when the partner was incentivized to be fair. Similarly, computational modeling showed that increased persecutory ideation was associated with greater beliefs of a partner's spitefulness. Twins with greater beliefs of a partner's spitefulness (relative to their co-twins) also reported higher persecution. In addition, twin differences in left lateral OFC activation during the task were associated with spite sensitivity. These results point towards a potentially causal role of the lateral OFC on spite sensitivity, and in turn effects of spite sensitivity on persecutory ideation.

Indexed as

BrainTrustAdolescentAdultBrain MappingDecision MakingFemaleGames, ExperimentalHumansMagnetic Resonance ImagingMaleTwins, MonozygoticYoung AdultComputational modelDecision-makingRewardSchizophreniaTwin study

Identifiers

PMID40640637
PMCPMC12615576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.