ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Regional limb cooling for the prevention of chemotherapy-induced toxicities: a narrative review.
Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review.Drug delivery · 2026Pooled it
- TAR-0520, a new candidate in oncodermatology: Results of a phase 1 program in healthy volunteers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- ITF6475, a New Histone Deacetylase 6 Inhibitor, Prevents Painful Neuropathy Induced by Paclitaxel.Toxics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChemotherapy-induced peripheral neuropathy (CIPN), hand-foot syndrome (HFS), and nail changes are common adverse effects associated with chemotherapy, significantly impacting the quality of life of cancer patients, and effective interventions remain an unmet need in oncologic care. Regional limb cooling is an emerging non-pharmacological approach used to prevent or reduce the severity of these adverse side effects. Although the awareness of regional limb cooling is rather prevalent, the overall use and efficacy of this non-pharmacological therapy in preventing chemotoxicities is not universally agreed upon. This paper reviews the current evidence regarding the use, efficacy, limitations, and safety of regional limb cooling in preventing or reducing CIPN, HFS, and nail changes in clinical settings.
methodsA literature review was conducted using the PubMed database to identify the most recent English articles published between 2004 and 2024 regarding the use of regional limb cooling to prevent CIPN, HFS, and nail changes.
resultsBased on the reviewed studies, regional limb cooling can potentially be a low-risk, non-pharmacological intervention that can prevent and reduce common and debilitating chemotherapy-induced toxicities. Although the studies described in this paper demonstrate encouraging results, there is still notable variability in efficacy.
conclusionThis underscores the need for randomized controlled trials, device innovation, and standardized protocols in regional limb cooling to properly demonstrate its potential for alleviating these common, debilitating conditions and enabling patients to adhere to their chemotherapy regimens more comfortably. This would thereby enhance overall cancer treatment tolerability and lead to safer, more patient-centered chemotherapy management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.