Effectiveness of Pharmacotherapy and Technical Modifications as Adjunctive Tools for Enhancing Weight Loss After Bariatric Endoscopy (Endoscopic Gastric Remodeling and Transoral Outlet Reduction): A Meta-analysis.

Abdul-Rahman Fadi Diab, Joseph Sujka, Stephanie Rivera Saavedra, Shravya Pingili, Rohit Nalamati, Salvatore Docimo, Christopher DuCoin

Abstract readMeta-AnalysisSystematic Review

PubMed Publisher

In one paragraph

Synthesis in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdul-Rahman Fadi DiabUniversity of Central Florida College of Medicine/HCA Healthcare GME Consortium, 1431 SW 1 st Ave, Ocala, FL, 34471, USA. a.diab94@hotmail.com.

Joseph SujkaDivision of Gastrointestinal Surgery, Department of Surgery, University of South Florida Morsani College of Medicine, 5 Tampa General Circle, Tampa, FL, 33606, USA.

Stephanie Rivera SaavedraUniversity of Central Florida College of Medicine/HCA Healthcare GME Consortium, 1431 SW 1 st Ave, Ocala, FL, 34471, USA.

Shravya PingiliUniversity of Central Florida College of Medicine/HCA Healthcare GME Consortium, 1431 SW 1 st Ave, Ocala, FL, 34471, USA.

Rohit NalamatiUniversity of Central Florida College of Medicine/HCA Healthcare GME Consortium, 1431 SW 1 st Ave, Ocala, FL, 34471, USA.

Salvatore DocimoDivision of Gastrointestinal Surgery, Department of Surgery, University of South Florida Morsani College of Medicine, 5 Tampa General Circle, Tampa, FL, 33606, USA.

Christopher DuCoinDivision of Gastrointestinal Surgery, Department of Surgery, University of South Florida Morsani College of Medicine, 5 Tampa General Circle, Tampa, FL, 33606, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The latest bariatric endoscopic techniques include transoral outlet reduction (TOR) and bariatric endoscopic gastric remodeling (BEGR). Weight loss and comorbidity resolution outcomes from bariatric endoscopy remain inferior to those of bariatric surgery. Additionally, some patients are either ineligible for or prefer not to undergo surgery. These factors have driven the development of adjunctive tools to enhance weight loss following bariatric endoscopy. Current tools include pharmacotherapy and technical modifications. This study reviews the effectiveness of such tools in enhancing weight loss after bariatric endoscopy. A systematic review and meta-analysis were conducted comparing BEGR with and without pharmacotherapy and TOR with and without a technical modification. The findings suggest that these adjunctive tools may improve weight loss outcomes, but given study limitations, definitive conclusions cannot be drawn.

Indexed as

Bariatric SurgeryObesity, MorbidWeight LossHumansTreatment OutcomeAnti-obesity medicationsBariatric endoscopyEndoscopic sleeve gastroplastyPharmacotherapyTransoral outlet reduction

Identifiers

PMID40640598

DOI10.1007/s11695-025-08053-7

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.