Evidence map›Paper›PMID 40640548›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Less invasive surfactant administration in the delivery room: A quality improvement initiative.

Jonathan R Burris, Blair F Germain, Patricia R Chess, Elizabeth A Powers, Rebecca Gillis, Hyacinth G Lewis, Jamey Tulloch, Colby L Day, Andrew M Dylag

Abstract read
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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonathan R BurrisDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY, 14642, USA. jonathan_burris@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-9340-2505
Blair F GermainDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY, 14642, USA.ORCID http://orcid.org/0009-0005-1319-9893
Patricia R ChessDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY, 14642, USA.
Elizabeth A PowersDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY, 14642, USA.
Rebecca GillisDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY, 14642, USA.
Hyacinth G LewisDepartment of Nursing, University of Rochester Medical Center, Rochester, NY, 14642, USA.ORCID http://orcid.org/0009-0003-8255-5260
Jamey TullochDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY, 14642, USA.
Colby L DayDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY, 14642, USA.ORCID http://orcid.org/0000-0003-1297-2571
Andrew M DylagDepartment of Pediatrics, Division of Neonatology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY, 14642, USA.ORCID http://orcid.org/0000-0001-5085-5873

Funding

The Role of Lung Megakaryocytes in Airway Disease after Neonatal HyperoxiaK08HL155491 · NHLBI · UNIVERSITY OF ROCHESTER · PI Andrew Michael Dylag · 2022 to 2026
$811k
U.S. Department of Health & Human Services | National Institutes of Health (NIH) K08HL155491
6 · The paper itself

Abstract

objectiveTo evaluate less invasive surfactant administration (LISA) in the delivery room as a part of neonatal stabilization and reduce infants requiring intubation. PROJECT

designA SMART aim was developed to implement LISA in >30% of infants (25.0-31.6 weeks' gestational age) with respiratory distress syndrome (RDS) in the NICU or delivery room (DR) and increase the number of infants never requiring intubation by 50% by 12/31/2023. Three sequential Plan-Do-Study-Act cycles were implemented. Statistical Process Control charts tracked time-ordered data.

resultsOver 4 years, 184 patients received LISA (N = 112 in the DR). LISA was safe and successful (98.9%), including DR. DR intubations were reduced (65.5 to 52.6%), infants never requiring intubation increased (22.8 to 38%), and Grade 2 or 3 BPD (12.9 to 8.8%) was reduced.

conclusionLISA in the delivery room is safe and effective for RDS and associated with reduced need for intubation, mechanical ventilation, and BPD.

Indexed as

Delivery RoomsPulmonary SurfactantsQuality ImprovementRespiratory Distress Syndrome, NewbornFemaleGestational AgeHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalIntubation, IntratrachealMalePulmonary Surfactants

Identifiers

PMID40640548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.