Evidence map›Paper›PMID 40640509›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum.

Selen Dirik, Michelle R Doyle, Courtney P Wood, Paola Campo, Angelica R Martinez, McKenzie Fannon, Maria G Balaguer, Spencer Seely, Bryan A Montoya, Gregory M R Cook and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Selen DirikDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID http://orcid.org/0009-0006-2429-4252
Michelle R DoyleDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4303-2478
Courtney P WoodDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Paola CampoDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Angelica R MartinezDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
McKenzie FannonDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Maria G BalaguerDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Spencer SeelyDepartment of Pathology, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Bryan A MontoyaDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Gregory M R CookDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Gabrielle M PalermoDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Junjie LinDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Madelyn D SistDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Parsa K NaghshinehDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Zihang LanDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Sara R M U RahmanDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Raymond SuhandynataDepartment of Pathology, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Paul SchweitzerDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.
Marsida KallupiDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8688-709X
Giordano de GuglielmoDepartment of Psychiatry, University of California San Diego, School of Medicine, La Jolla, CA, USA. gdeguglielmo@health.ucsd.edu.ORCID http://orcid.org/0000-0002-4782-7430

Funding

Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Identification of Genetic Variants that Influence Compulsive Alcohol Intake in Outbred RatsR01AA030048 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Giordano De Guglielmo · 2023 to 2026
$1.7M
NIAAA NIH HHS R01 AA030048NIAAA NIH HHS T32 AA007456
6 · The paper itself

Abstract

Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments. Cannabidiol (CBD), a non-psychotropic constituent of cannabis, shows promise in modulating addictive behaviors. This study investigated the effects of chronic CBD administration on alcohol dependence, withdrawal symptoms, and neurodegeneration using two complementary rodent models: chronic intermittent ethanol (CIE) exposure, which models established alcohol dependence, and ethanol vapor self-administration (EVSA), which captures the volitional aspects of alcohol intake. In the CIE model, CBD reduced alcohol self-administration during acute withdrawal without affecting alcohol metabolism or locomotor activity. CBD decreased motivation for alcohol, somatic withdrawal signs, withdrawal-induced anxiety-like behaviors, and mechanical sensitivity. During extinction, CBD attenuated alcohol-seeking behavior and stress-induced reinstatement. Electrophysiological recordings revealed that CBD reversed alcohol-induced decreases in neuronal excitability in the basolateral amygdala, suggesting a mechanism involving normalization of neural function. In the EVSA model, CBD reduced voluntary alcohol intake during the escalation phase, impacting voluntary alcohol intake. This effect was specific to alcohol-related behaviors, as it did not affect saccharin self-administration. Immunohistochemical analyses showed that CBD prevented alcohol-induced neurodegeneration in the nucleus accumbens shell and dorsomedial striatum, regions implicated in the volitional control of alcohol consumption. These findings indicate that chronic CBD administration attenuates both behavioral and neurobiological facets of alcohol dependence by modulating neuronal excitability and preventing neurodegeneration, supporting its therapeutic potential for AUD and providing mechanistic insights for future research.

Indexed as

AlcoholismBasolateral Nuclear ComplexCannabidiolCorpus StriatumNeuroprotective AgentsSubstance Withdrawal SyndromeAnimalsDisease Models, AnimalDrug-Seeking BehaviorEthanolMaleMotivationRatsRats, Sprague-DawleySelf AdministrationCannabidiolEthanolNeuroprotective Agents

Identifiers

PMID40640509
PMCPMC12404032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.