Evidence map›Paper›PMID 40640501›Full record

ArticleNature cell biology2025

Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation.

Samy Kefalopoulou, Pim M J Rullens, Kim L de Luca, Sandra S de Vries, Tessy Korthout, Alexander van Oudenaarden, Peter Zeller, Jop Kind

Abstract read
In one paragraph

Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Genome-wide chromatin recording resolves dynamic cell state changes.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samy Kefalopoulou *Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-7565-9614
Pim M J Rullens *Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0009-0007-4176-5674
Kim L de LucaHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-5900-5100
Sandra S de VriesHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.
Tessy KorthoutHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.
Alexander van OudenaardenHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-9442-3551
Peter ZellerHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands. peter.zeller@mbg.au.dk.ORCID http://orcid.org/0000-0003-2537-0254
Jop KindHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, The Netherlands. j.kind@hubrecht.eu.ORCID http://orcid.org/0000-0001-7538-2638

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 798573Human Frontier Science Program (HFSP) LT000209/2018-LNederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) 016.161.339Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) NWO-CW714.016.001
6 · The paper itself

Abstract

The regulation of gene expression is governed at multiple levels of chromatin organization. However, how gene regulation is co-ordinated remains relatively unexplored. Here we develop Dam&ChIC, a method that enables retrospective and multifactorial chromatin profiling in single cells. Dam&ChIC employs chromatin labelling in living cells with

Indexed as

ChromatinChromatin Assembly and DisassemblySingle-Cell AnalysisX Chromosome InactivationAnimalsFemaleHumansMiceRNA, Long NoncodingX ChromosomeChromatinRNA, Long NoncodingXIST non-coding RNA

Identifiers

PMID40640501
PMCPMC12270907

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.