ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Oral mucositis in patients undergoing hematopoietic stem cell transplantation with prophylactic photobiomodulation: A retrospective cohort study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo analyze the incidence, severity, and factors associated with the development of oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT) who are receiving prophylactic photobiomodulation therapy (PBMT).
methodsData, including sex, age, grade of OM, and conditioning regimen, were collected from medical records of patients undergoing prophylactic PBMT at a reference hospital in Brazil. Pearson's chi-square test or Fisher's exact test were applied to examine the associations between variables. Kaplan-Meier method was used to calculate disease-free survival time.
resultsA total of 68 patients were included in the study, 54.4% of whom were female, with a median age of 40 years. OM occurred in 37 patients (54.4%). Most OMs were classified as Grade 0 (45.5%). No cases of Grade 3 or 4 OM were observed. A statistically significant association was found between Grade 1 and 2 OM and younger age (p = 0.017). FluBuMel/Cy conditioning regimen was associated with the occurrence of Grade 2 OM (p = 0.006), while pharyngeal mucositis was associated with Grade 1 (p < 0.0001). Age, pharyngeal mucositis and some types of conditioning regimen had a significant impact on the disease-free survival rate for OM. Patients undergoing the MEL100 conditioning protocol had a 14.36-fold increased risk of developing this complication.
conclusionIn HSCT patients undergoing prophylactic use of PBMT, factors such as age, specific chemotherapy conditioning protocols, and the presence of pharyngeal mucositis were found to be associated with OM development.
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