ArticleDiscover oncology2025
Unveiling the therapeutic potential of senescence-related IQGAP2 in pancreatic Cancer through post-GWAS genomic and scRNA-seq analyses.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Identification of neutrophil extracellular traps-related genes as feature genes and potential therapeutic targets in pulmonary hypertension.Journal of thoracic disease · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundPancreatic cancer (PC) is a highly aggressive tumor with a poor prognosis and few treatment options available. While cellular senescence has been linked to the advancement of various cancers, its specific role in PC is not well understood.
methodWe employed Mendelian randomization (MR) alongside single-cell RNA sequencing (scRNA-seq) to explore the involvement of senescence-associated genes (SAGs) in PC. A summary-data-based MR (SMR) analysis was performed to evaluate the connection between SAG expression and the risk of developing PC, using HEIDI test and colocalization analysis to reduce confounding variables. Additionally, scRNA-seq data were used to further examine SAG expression within pancreatic cancer cells and assess their potential as therapeutic targets.
resultsThe SMR analysis revealed a significant correlation between IQGAP2 expression levels and the risk of PC (P_
conclusionThere is a strong association between IQGAP2 and the risk factors for the progression of PC, positioning it as an attractive candidate for targeted therapies. This investigation sheds new light on mechanisms underlying PC while paving the way for precision-targeted treatment strategies.
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