ArticleCardiovascular and interventional radiology2025
Cryoneurolysis: Parallel Growth in PubMed Publications and Google Trends Analysis Reveals Exponential Interest.
Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evaluation of interest trends among the general population and scientific community in migraine surgery.JPRAS open · 2026Article
- Interest Trajectories of Emerging Embolization Procedures: A Google Trends and PubMed Analysis.Cardiovascular and interventional radiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption. MATERIALS AND
methodsRetrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993-2025) using the keyword "cryoneurolysis." Statistical analyses included Mann-Kendall trend tests, Portmanteau white noise tests, Dickey-Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression.
resultsSearch interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3-4 years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p < 0.0001; Google Trends: τ = 0.75, p < 0.0001). Commercial driver "Iovera" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8-50.4) in 2025 to 72.6 (95% CI: 59.2-86.0) by 2030.
conclusionAnalysis reveals parallel academic-public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030.
Indexed as
Identifiers
40640413What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.