Evidence map›Paper›PMID 40640410›Full record

ArticleCardiovascular and interventional radiology2025

CT-guided Thermal Ablation of Liver Tumors Using Intraprocedural CT-CT Fusion for Applicator Position and Ablation Completeness Assessment: a Single-Center Comparative Analysis.

Koen H M Verdonschot, Sjoerd F M Jenniskens, Peter B van den Boezem, Eric T T L Tjwa, Johannes H W de Wilt, Jurgen J Fütterer, Martijn W J Stommel, Christiaan G Overduin

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Koen H M VerdonschotDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands. Koen.verdonschot@radboudumc.nl.ORCID http://orcid.org/0009-0005-2789-6913
Sjoerd F M JenniskensDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Peter B van den BoezemDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Eric T T L TjwaDepartment of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Johannes H W de WiltDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Jurgen J FüttererDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Martijn W J StommelDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Christiaan G OverduinDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare outcomes of CT-guided thermal ablation of liver tumors with versus without use of intraprocedural CT-CT image fusion. MATERIALS AND

methodsThis retrospective cohort study included all patients treated with CT-guided percutaneous thermal ablation for hepatocellular carcinoma (HCC) or colorectal liver metastases (CRLM) between January 2017 and April 2023 at our institution. From October 2019, intraprocedural CT-CT deformable image fusion (IF) using dedicated software (Vitrea, Canon Medical) was introduced to the thermal ablation procedure workflow to visually assess applicator placement before ablation and ablation completeness posttreatment. Local tumor progression (LTP) was assessed on follow-up imaging. LTP-free survival (LTPFS) between groups with and without IF was estimated with the Kaplan-Meier method and risk factors for LTP were identified with Cox regression analysis.

resultsA total of 113 patients treated in 139 sessions were included; 66 treatments for 86 tumors without use of IF (56 HCC; 30 CRLM) and 73 treatments for 92 tumors with use of IF (46 HCC; 46 CRLM). Two-year LTPFS was significantly improved with use of IF for both HCC (97% vs. 74%; p = .009) and CRLM (82% vs. 56%; p = .033). On univariate regression analysis, use of IF was a predominant factor significantly associated with improved LTPFS in patients with HCC (HR: 0.21, p = .037) and CRLM (HR: 0.38, p = .042).

conclusionIn this single-center study, the use of software-based intraprocedural CT-CT image fusion for applicator position and ablation completeness assessment was associated with improved local tumor progression-free survival after CT-guided thermal ablation of HCC and CRLM. LEVEL OF EVIDENCE: 3:

Indexed as

Carcinoma, HepatocellularColorectal NeoplasmsLiver NeoplasmsRadiography, InterventionalTomography, X-Ray ComputedAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeImage fusionLiver malignanciesLocal tumor progression-free survival (LTPFS)Thermal ablation

Identifiers

PMID40640410
PMCPMC12464092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.