Evidence map›Paper›PMID 40640348›Full record

ArticleScientific reports2025

Ptychoscopy: a user friendly experimental design tool for ptychography.

Radim Skoupy, Elisabeth Müller, Timothy J Pennycook, Manuel Guizar-Sicairos, Emiliana Fabbri, Emiliya Poghosyan

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ptychography at all wavelengths.Nature reviews. Methods primers · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Radim SkoupyPSI Center for Life Sciences, Paul Scherrer Institute, PSI, Villigen, 5232, Switzerland.
Elisabeth MüllerPSI Center for Life Sciences, Paul Scherrer Institute, PSI, Villigen, 5232, Switzerland.
Timothy J PennycookEMAT, Department of Physics, University of Antwerp, Groenenborgerlaan 171, Antwerp, 2020, Belgium.
Manuel Guizar-SicairosPSI Center for Photon Science, Paul Scherrer Institute, PSI, Villigen, 5232, Switzerland.
Emiliana FabbriPSI Center for Energy and Environmental Sciences, Paul Scherrer Institute, PSI, Villigen, 5232, Switzerland.
Emiliya PoghosyanPSI Center for Life Sciences, Paul Scherrer Institute, PSI, Villigen, 5232, Switzerland. emiliya.poghosyan@psi.ch.

Funding

HORIZON EUROPE European Research Council No. 802123-HDEMPaul Scherrer Institut PSI research grant2021
6 · The paper itself

Abstract

Electron ptychography is a rapidly growing diffractive imaging technique providing superior image contrast, high resolution, efficient dose usage and versatile imaging conditions. Originally coming from the physical sciences, it has also become a method of interest in the life sciences. Regardless of the scientific field, the successful ptychographic reconstruction relies on various combinations of adjustable experimental parameters, along with the choice of the reconstruction algorithm. In this work we present ptychoScopy, a Python-based tool developed to simplify the selection of these parameters and aid successful experimental design. Using a [Formula: see text] sample, we show the influence of key parameters such as probe convergence angle, defocus and electron dose on the reconstruction quality using direct and iterative reconstruction algorithms. We investigate the influence of real and reciprocal space sampling and their influence on the speed and quality of ptychographic reconstructions. PtychoScopy simplifies experimental design and guides the researchers across diverse scientific fields in setting up successful ptychographic experiments.

Indexed as

Electron ptychographyExperimental designReal- and reciprocal space sampling

Identifiers

PMID40640348
PMCPMC12246451

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.