Evidence map›Paper›PMID 40640334›Full record

ArticleOncogene2025

The tumor suppressor pRb and its relative p130 are required to maintain murine adult skeletal muscle homeostasis.

Zhe Jiang, Brittany L Baechler, Huiqin Li, Heta Lad, Giovanni Ciavarra, Yaacov Ben-David, Steven J Burden, Joe Quadrilatero, Eldad Zacksenhaus

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhe JiangToronto General Research Institute-University Health Network, Toronto, ON, Canada. zhe.jiang@uhn.ca.ORCID http://orcid.org/0000-0003-2895-1476
Brittany L BaechlerDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Huiqin LiToronto General Research Institute-University Health Network, Toronto, ON, Canada.
Heta LadToronto General Research Institute-University Health Network, Toronto, ON, Canada.
Giovanni CiavarraToronto General Research Institute-University Health Network, Toronto, ON, Canada.
Yaacov Ben-DavidState Key Laboratory for Discovery and Utilization of Functional Component in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, Guizhou, China.ORCID http://orcid.org/0000-0002-9020-6074
Steven J BurdenNeurology Department, Massachusetts General Hospital, Charlestown, MA, USA.
Joe QuadrilateroDepartment of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Eldad ZacksenhausToronto General Research Institute-University Health Network, Toronto, ON, Canada. eldad.zacksenhaus@utoronto.ca.ORCID http://orcid.org/0000-0001-6104-6094

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The retinoblastoma tumor suppressor pRB is required for skeletal myogenesis but its role in maintenance of post-mitotic skeletal muscle and the contribution, if any, of its relatives, p107 and p130, are largely unknown. Here, we show that targeted deletion of murine Rb in proliferating myoblasts during myogenesis, using a Pax7-Cre deleter line, leads to muscle fiber degeneration, short myotubes with elongated, large nuclei, reduced late muscle marker expression, and fetal death. These defects are recapitulated in primary myoblasts derived from Pax7-Cre:Rb

Indexed as

HomeostasisMuscle, SkeletalRetinoblastoma-Like Protein p130Retinoblastoma ProteinAnimalsAutophagyMiceMice, KnockoutMuscle DevelopmentMyoblastsPAX7 Transcription FactorRetinoblastoma-Like Protein p107Pax7 protein, mousePAX7 Transcription FactorRetinoblastoma-Like Protein p107Retinoblastoma-Like Protein p130Retinoblastoma Protein

Identifiers

PMID40640334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.