Evidence map›Paper›PMID 40640300›Full record

ArticleScientific reports2025

DSP and DPP are dispensable for initiation of dentin and enamel mineralization but critical for circumpulpal dentin mineralization.

Tian Liang, Charles E Smith, Yuanyuan Hu, Hong Zhang, Chuhua Zhang, James P Simmer, Jan C-C Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tian LiangDepartment of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, MI, 48109, USA. tianl@umich.edu.
Charles E SmithDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, MI, 48109, USA.
Yuanyuan HuDepartment of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, MI, 48109, USA.
Hong ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, MI, 48109, USA.
Chuhua ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, MI, 48109, USA.
James P SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, MI, 48109, USA.
Jan C-C HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, MI, 48109, USA.

Funding

DSPP Function, Pathophysiology, and Genetic DiagnosisR01DE027675 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMMER, JAMES P · 2018 to 2022
$2.4M
Ameloblast-specific mineral ribbon attachment/elongation complex in enamel formationR00DE030858 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TIAN LIANG · 2024 to 2026
$747k
Development and Validation of Novel Amelogenesis ModelsUH3DE028849 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2021 to 2022
$621k
Leica SP8 Confocal MicroscopeS10OD028612 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANTONETTI, DAVID · 2021 to 2021
$599k
Ameloblast-specific mineral ribbon attachment/elongation complex in enamel formationK99DE030858 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIANG, TIAN · 2022 to 2023
$203k
NIDCR NIH HHS DE027675NIDCR NIH HHS K99 DE030858NIDCR NIH HHS R00 DE030858NIDCR NIH HHS R01 DE027675NIDCR NIH HHS UH3 DE028849NIH HHS S10 OD028612
6 · The paper itself

Abstract

Dentin sialophosprotein (DSPP) is cleaved into the N-terminal dentin sialoprotein (DSP) proteoglycan and the C-terminal dentin phosphoprotein (DPP; the most acidic proteins in humans). To define the functions of DSP and DPP, we generated a Dspp

Indexed as

Calcification, PhysiologicDental EnamelDentinExtracellular Matrix ProteinsPhosphoproteinsSialoglycoproteinsTooth CalcificationAnimalsDentin SialophosphoproteinMiceMice, Inbred C57BLMice, KnockoutOdontoblastsDentin SialophosphoproteinExtracellular Matrix ProteinsPhosphoproteinsSialoglycoproteinsBiomineralizationDentinDentin mineralizationDentin phosphoproteinDentin SialophosphoproteinDentin sialoprotein

Identifiers

PMID40640300
PMCPMC12246090

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.