Complex regional pain syndrome and use of psychotropic drugs as a proxy for psychological health.

Lars B Dahlin, Raquel Perez, Erika Nyman, Malin Zimmerman, Juan Merlo

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Use of processed nerve allograft to relieve pain and restore function in individuals with painful upper limb neuroma-a case series of five individuals.Frontiers in surgery · 2026
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5 authors.

Lars B DahlinDepartment of Translational Medicine - Hand Surgery, Lund University, Skåne University Hospital, Jan Waldenströms g 5, SE-20502, Malmö, Sweden. Lars.Dahlin@med.lu.se.

Raquel PerezDepartment of Translational Medicine - Hand Surgery, Lund University, Skåne University Hospital, Jan Waldenströms g 5, SE-20502, Malmö, Sweden.

Erika NymanDepartment of Biomedical and Clinical Sciences, Linköping University, SE- 58183, Linköping, Sweden.

Malin ZimmermanDepartment of Translational Medicine - Hand Surgery, Lund University, Skåne University Hospital, Jan Waldenströms g 5, SE-20502, Malmö, Sweden.

Juan MerloUnit for Social Epidemiology, Department of Clinical Sciences (Malmö), Faculty of Medicine, Lund University, SE-20502, Malmö, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate the association between psychotropic drug use (proxy for psychological health) and Complex Regional Pain Syndrome (CRPS) type 1 and type 2 in upper and lower limbs. We also assessed the impact of demographic and socioeconomic factors. From a national record linkage database [4,706,821 individuals (25-64 years); CRPS type 1 = 809; type 2 = 225], prevalence ratios (PR), absolute risk (AR), and AR difference (ARD) [95% confidence intervals (CI)] were estimated by logistic and Cox regressions with constant time at risk. About 36% of CRPS individuals consumed psychotropic drugs (reference: general population 15%). Unadjusted PRs were two times higher in nerve injuries/disorders without CRPS [PR = 1.78; 95% CI: 1.73-1.82] and CRPS type 1 [2.33 (2.07-2.62)] and almost three times higher in CRPS type 2 [2.79 (2.27-3.42)]. Higher ARDs were observed in type 2, independent of level of income, and were higher for the high-income category. In type 2, ARDs were higher for middle-high/high occupational status levels. Higher ARDs were observed in nerve injuries/nerve disorders, CRPS type 1, and type 2 in immigrants, especially high for type 2. Regarding most age intervals, ARDs were higher for individuals with CRPS type 2. Individuals with CRPS, especially type 2, have high risk of impaired psychological health.

Indexed as

Complex Regional Pain SyndromesMental HealthPsychotropic DrugsAdultFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsSocioeconomic FactorsPsychotropic Drugs

Identifiers

PMID40640245

DOI10.1038/s41598-025-09701-9

PMCPMC12246038

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