ArticleNPJ Parkinson's disease2025
Theta-frequency subthalamic stimulation enhances conflict resolution in Parkinson's disease patients with freezing of gait through frontal cortex modulation.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cerebellar Atrophy Modulates Freezing of Gait in Multiple System Atrophy Through Cognitive Dysfunction.CNS neuroscience & therapeutics · 2026Article
- Cognitive effects of STN-DBS on mental rotation performance in Parkinson's disease.Scientific reports · 2026Article
- Theta-frequency subthalamic nucleus deep brain stimulation selectively improves visual attention in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- A multimodal machine learning model for predicting postoperative worsening of FOGQ in Parkinson's disease following STN-DBS.Frontiers in neurologyArticle
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Authors and funding
15 authors.
Funding
Abstract
Freezing of gait (FOG) in Parkinson's disease (PD) is a debilitating motor symptom linked to executive dysfunction, particularly impaired conflict resolution. However, the underlying neural mechanisms and optimal treatment remain unclear. We assessed conflict resolution using a modified Flanker task in 90 PD patients (52 with FOG) and 37 healthy controls. PD-FOG patients exhibited significantly greater conflict costs than patients without FOG and healthy controls. Task-based fMRI revealed enhanced frontal cortical activation associated with conflict processing deficits in PD-FOG, positively correlating with FOG severity. In a subgroup of 18 PD-FOG patients undergoing fMRI during subthalamic nucleus deep brain stimulation (STN-DBS), theta-frequency (5 Hz) stimulation improved conflict resolution and increased frontal activation, whereas high-frequency (130 Hz) stimulation primarily activated motor regions without cognitive benefit. These findings indicate that frontal dysfunction contributed to the conflict resolution deficits in PD-FOG and support theta-frequency STN-DBS as a promising therapeutic approach for enhancing cognitive function.
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