Evidence map›Paper›PMID 40640146›Full record

ArticleNature communications2025

Structural basis for catalysis by human lipoyl synthase.

Olga A Esakova, Douglas M Warui, Syam Sundar Neti, John N Alumasa, Squire J Booker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Olga A EsakovaDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA. oae3@sas.upenn.edu.ORCID http://orcid.org/0000-0001-8377-8368
Douglas M WaruiDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Syam Sundar NetiDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0003-3343-8642
John N AlumasaDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.
Squire J BookerDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA. sjbooker@mac.com.ORCID http://orcid.org/0000-0002-7211-5937

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Radical Mechanisms of Iron-Sulfur ProteinsR35GM122595 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SQUIRE J. BOOKER · 2017 to 2026
$3.4M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
National Science Foundation (NSF) MCB-171668NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R35 GM122595NIH HHS S10 OD012289U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM-122595
6 · The paper itself

Abstract

Lipoic acid is an essential cofactor in five mitochondrial multiprotein complexes. In each complex, it is tethered in an amide linkage to the side chain of a conserved lysyl residue on a lipoyl carrier protein or lipoyl domain to afford the lipoyl cofactor. Lipoyl synthase catalyzes the last step in the biosynthesis of the lipoyl cofactor, the addition of two sulfur atoms to carbons 6 and 8 of an octanoyllysyl residue of the H protein, the lipoyl carrier protein of the glycine cleavage system. Lipoyl synthase, a member of the radical S-adenosylmethionine superfamily, contains two [Fe

Indexed as

SulfurtransferasesBiocatalysisCatalysisCatalytic DomainCrystallography, X-RayHumansIron-Sulfur ProteinsModels, MolecularThioctic AcidIron-Sulfur ProteinsLIAS protein, humanSulfurtransferasesThioctic Acid

Identifiers

PMID40640146
PMCPMC12246082

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.