Evidence map›Paper›PMID 40640044›Full record

SynthesisBritish journal of anaesthesia2025

Are adults with chronic pain more likely to develop hypertension than adults without chronic pain? A systematic review and meta-analysis.

Harriet E Taylor, Joseph C Salf, Charlotte R Roper-Marchand, Dhaneesha N S Senaratne, Blair H Smith, Lesley A Colvin, Jacob George

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Harriet E TaylorChronic Pain Research Group, Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Joseph C SalfNHS Tayside, Ninewells Hospital and Medical School, Dundee, UK.
Charlotte R Roper-MarchandNHS Tayside, Ninewells Hospital and Medical School, Dundee, UK.
Dhaneesha N S SenaratneChronic Pain Research Group, Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Blair H SmithChronic Pain Research Group, Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Lesley A ColvinChronic Pain Research Group, Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK. Electronic address: l.a.colvin@dundee.ac.uk.
Jacob GeorgeCardiovascular Research, School of Medicine, University of Dundee, Dundee, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn association between persistent pain and blood pressure is increasingly recognised but is not fully understood. In this systematic review, we aimed to establish whether chronic pain (CP) is associated with a diagnosis of hypertension (HTN).

methodsAfter prospective registration (PROSPERO ID: CRD42025629486), we searched six databases from inception until January 8, 2025, for studies investigating the association between CP and HTN. Title and abstract screening, full-text review, data extraction, and risk of bias assessment were performed by two independent reviewers. Study quality assessment used the Risk of Bias In Non-randomised Studies of Exposures (ROBINS-E) tool. Meta-analysis was conducted using a random effects model.

resultsFrom 7973 records, we identified 23 eligible studies for inclusion, of which 20 provided suitable data for meta-analysis (total participants n=1 594 264). The pooled odds ratio for HTN in people with CP compared with controls was 1.66 (95% confidence interval [CI] 1.28-2.15) with high inter-study heterogeneity (I

conclusionsIn line with a growing body of evidence in this field, this systematic review and meta-analysis confirms an association between chest pain and hypertension. Further research is warranted to understand this association and elucidate any mediating factors. SYSTEMATIC REVIEW PROTOCOL: PROSPERO (CRD42025629486).

Indexed as

Chronic PainHypertensionAdultHumansback painchronic headachechronic painfibromyalgiahypertension

Identifiers

PMID40640044
PMCPMC12489386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.