Fluorogenic Coumarins Activated via Bioorthogonal Reactions.

Halley M Lin-Jones, Sharon Chen, Yeonseong Seo, Kelly Q Pham, Jennifer A Prescher

Abstract read

In one paragraph

Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Fluorogenic Coumarins Activated via Bioorthogonal Reactions.The Journal of organic chemistry · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Halley M Lin-JonesDepartment of Chemistry, University of California, Irvine, California 92697, United States.

Sharon ChenDepartment of Chemistry, University of California, Irvine, California 92697, United States.

Yeonseong SeoDepartment of Chemistry, University of California, Irvine, California 92697, United States.ORCID 0000-0002-0451-9825

Kelly Q PhamDepartment of Chemistry, University of California, Irvine, California 92697, United States.

Jennifer A PrescherDepartment of Chemistry, University of California, Irvine, California 92697, United States.ORCID 0000-0002-9250-4702

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026

$57.9M

NCI NIH HHS P30 CA062203

6 · The paper itself

Abstract

Fluorogenic bioorthogonal reagents enable facile detection in complex environments. While useful for real-time imaging, few such probes are available. Existing tools also exploit similar mechanisms for signal turn-on, precluding multiplexed applications. To address these gaps, we developed a palette of cyclopropenone (CpO) scaffolds that are activated by bioorthogonal phosphines to produce coumarins. The top CpO-phosphine pairs show strong fluorescent enhancements (up to 760-fold), high quantum yields, and stability in aqueous environments. The CpO fluorogens also exhibit unique reaction profiles, setting the stage for multicomponent labeling studies.

Identifiers

PMID40639935

DOI10.1021/acs.joc.5c01117

PMCPMC12591267

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.