Evidence map›Paper›PMID 40639905›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Image-Derived Blood Normalization of Antibody-Based TREM2 PET in Mouse Models of Amyloidosis and Myocardial Infarction.

Rebecca Schaefer, Lea H Kunze, Marlies Haertel, Yeqian Zhu, Kai Schlepckow, Michael Willem, Laura M Bartos, Giovanna Palumbo, Lukas Tomas, Christian Schulz and 8 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rebecca SchaeferDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Lea H KunzeDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Marlies HaertelDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Yeqian ZhuInstitute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, Munich, Germany.
Kai SchlepckowGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Michael WillemChair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.
Laura M BartosDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Giovanna PalumboDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Lukas TomasDepartment of Medicine I, LMU University Hospital, LMU Munich, Munich, Germany.
Christian SchulzDepartment of Medicine I, LMU University Hospital, LMU Munich, Munich, Germany.
Steffen MassbergDepartment of Medicine I, LMU University Hospital, LMU Munich, Munich, Germany.
Rudolf A WernerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Maximilian FischerDepartment of Medicine I, LMU University Hospital, LMU Munich, Munich, Germany.
Dan XiaDenali Therapeutics Inc., South San Francisco, California.
Kathryn M MonroeDenali Therapeutics Inc., South San Francisco, California.
Christian HaassGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Simon LindnerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany; simon.lindner@med.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The triggering receptor expressed on myeloid cells 2 (TREM2) plays a pivotal role in the activation of myeloid cells and is currently being investigated as a potential therapeutic target in several diseases. In this study, we established enhanced quantification of PET images of a

Indexed as

AmyloidosisMembrane GlycoproteinsMyocardial InfarctionPositron-Emission TomographyReceptors, ImmunologicAnimalsCopper RadioisotopesDisease Models, AnimalMiceMice, KnockoutCopper RadioisotopesMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouse64CuATV:4D9PETSPMTREM2

Identifiers

PMID40639905
PMCPMC12410300

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.