ArticleJournal of vascular surgery2025
Identifying the challenges of amputation prevention in a rural state with mixed methods research engaging patients and providers.
Article in Journal of vascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo identify barriers and facilitators to amputation prevention in a rural state using a mixed methods approach integrating spatial epidemiology, regression analysis, and qualitative methods.
methodsWe conducted a sequential explanatory mixed methods study in West Virginia, the only state entirely within Appalachia and among the most rural in the U.S. Quantitative analysis of 2011-2016 hospital discharge data from the State Inpatient Database (Healthcare Cost and Utilization Project) identified geographic disparities in diabetes/peripheral artery disease-related amputation using Bayesian spatial hierarchical modeling and multivariable regression. Qualitative interviews and focus groups were conducted with patients, caregivers, and providers from high-risk zip codes to explore the barriers and facilitators to limb preservation. Thematic analysis was used to identify emergent themes.
resultsAmputation rates in West Virginia were geographically clustered, with major amputations occurring at 5 per 1000 and minor amputations at 7 per 1000 patients. Regression models showed increased risk for those with peripheral artery disease complicating diabetes, Medicaid insurance, and rural residence. Sixty-six people participated in interviews and focus groups. Four major themes emerged: (1) lack of patient and provider education, (2) barriers to access and care coordination, (3) geographic and cultural challenges tied to rurality, and (4) treatment nonadherence linked to communication breakdowns and hopelessness.
conclusionsDisparities in amputation risk are driven by complex, inter-related factors in rural settings. Findings support the need for targeted interventions focused on provider and patient education, care coordination, mental health support, and culturally grounded community engagement. This framework may guide future efforts to decrease amputation rates in other underserved populations.
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