ArticleOphthalmology. Retina2026
Topographic Features in Retinopathy of Prematurity With en Face Ultra-Widefield OCT.
Article in Ophthalmology. Retina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Application of a Quantitative Vascular Severity Score in Retinopathy of Prematurity in the United States and India: New Insights Into Disease Epidemiology and Pathophysiology.American journal of ophthalmology · 2026Article
- Non-mydriatic handheld optical coherence tomography for panretinal imaging.Biomedical optics express · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
purposeThis study presents 2 methods of en face visualization enabled by ultra-widefield (UWF) OCT, which provide topographic information of retinopathy of prematurity (ROP) without requiring direct visualization of cross-sectional scans.
designEvaluation of diagnostic technology. SUBJECTS: Infants undergoing ROP screening at Oregon Health Science University between June 2023 and October 2024, who consented to research imaging.
methodsAn investigational contact-based UWF-OCT captured 800 × 800 A-scans. Max intensity projections (MIP) were constructed, from the highest intensity pixel in each A-scan's x-y coordinate plane. Retinal thickness maps (RTMs) were generated by first segmenting the retina with a previously trained U-net, then calculating the retinal thickness at each position in microns, and displaying it with a topographic colormap.
main outcome measuresCross-sectional and longitudinal qualitative evaluation of the diagnostic utility of MIP and RTM across the spectrum of ROP stage.
resultsMIP highlights areas of high signal attenuation, such as blood vessels and the atypical neurovascular thickening accompanying stage 1 or greater ROP. Retinal thickness maps reflect thickness information in the retina that highlights complementary aspects of the progression and spectrum of the stage. Retinal thickness maps also reveal subclinical elements of ROP morphology, such as the foveal contour, in some cases "stage 0" ROP, and cystoid macular edema.
conclusionsThis study presents 2 techniques to visualize pathology in ROP from UWF-OCT. Together, they enable both high-contrast visualization of the vascular features of ROP and the associated topographic changes across the spectrum of ROP. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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