ArticleJournal of the neurological sciences2025
Quantitative analysis of cerebral vasculature and its clinical effect on cognitive change in Alzheimer's dementia and mild cognitive impairment.
Article in Journal of the neurological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCerebrovascular disease (CVD) and Alzheimer's disease (AD) share common risk factors and often coexist. This study investigates the relationship between cerebral arterial features and cognitive decline in patients with clinical AD dementia and amnestic mild cognitive impairment (MCI) using quantitative analysis of Time-Of-Flight (TOF) magnetic resonance angiography (MRA).
methods131 patients (101 AD dementia, 30 amnestic MCI) underwent baseline TOF-MRA and cognitive assessments and 24-month follow-up cognitive tests. Total distal arterial length was measured using a custom-designed semi-automatic intracranial vascular map construction software. Associations between total distal arterial length and cognitive changes were analyzed using multiple linear regression and repeated measures analysis of covariance.
resultsShorter total distal arterial length was significantly associated with greater 2-year decline in Montreal Cognitive Assessment (MoCA) scores over 2 years (r = 0.199, p = 0.020). This association remained significant after adjusting for various confounding factors, including age, sex, education, brain parenchymal fraction, white matter hyperintensities, ApoE4 status, and vascular risk factors. Similar trends were observed for Mini-Mental State Examination (MMSE) scores, although not reaching statistical significance.
conclusionsQuantitative measurements of cerebral vasculature on TOF-MRA are independently associated with cognitive decline in patients with clinical AD dementia and amnestic MCI. This suggests that reduced cerebral blood flow may contribute to cognitive decline in these patients, highlighting the potential role of vascular factors in AD progression. These findings support the use of quantitative cerebral arterial measurements as a potential imaging biomarker for cognitive decline in AD.
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