ArticleLung cancer (Amsterdam, Netherlands)2025
Cell adhesion molecule-1 is a promising target for chimeric antigen receptors in lung adenocarcinoma.
Article in Lung cancer (Amsterdam, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The trinity of T cell engagement: navigating the molecular and clinical landscape of CAR-T, TILs, and TCEs in the war against cancer.Frontiers in immunology · 2026Review
- Predicting Clinical Outcomes and Immunotherapy Responses in Lung Adenocarcinoma Based on Nicotine Response Characteristics.Current medicinal chemistry · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Advances in targeted therapies, immune-checkpoint inhibitors, and chemo-immunotherapy combinations have improved survival in subsets of lung adenocarcinoma (LUAD) patients, yet novel treatments are needed for those who do not respond. We previously demonstrated that Cell Adhesion Molecule 1 (CADM1) is modulated by EMT-MET cycling in lung cancer cells, and mediates NK-mediated immune surveillance. In this study, CADM1 expression was confirmed on the cell surface, correlating with poor survival in LUAD patients, identifying it as a potential therapeutic target for chimeric antigen receptor (CAR) based approach. An anti-CADM1 chimeric antigen receptor (CAR) was developed, demonstrating robust CADM1-specific activity against lung cancer cells. CADM1-CAR-T cells exhibited a balanced composition of stem cell-like (T
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