ArticleHeart & lung : the journal of critical care
Inflammation markers associated with symptoms and neighborhood deprivation in black adults with heart failure.
Article in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Differential effects of neighborhood ambient PMInternational journal of health geographics · 2026Article
Corrections and comments
- Update of
Authors and funding
6 authors.
Funding
Abstract
backgroundBlack adults face a higher prevalence of heart failure (HF), with greater symptom burden and earlier onset compared to other populations. Systemic inflammation and socioeconomic factors, including neighborhood deprivation, contribute to these disparities. Understanding the interplay between inflammation, HF symptoms, and social determinants of health is critical for addressing inequities in HF outcomes.
objectivesThis study examines associations between inflammatory biomarkers and physical and psychological symptoms in Black adults with HF and explores the impact of neighborhood deprivation on these factors.
methodsBlack adults with HF (N = 41) were enrolled in this cross-sectional study. Blood samples were collected using Mitra Microsampling for biomarker analysis, including cytokines, chemokines, and xanthine oxidase (XO) activity. Symptoms were assessed using validated measures for dyspnea, fatigue, anxiety, depression, stress, and sleep disturbance. Neighborhood deprivation was evaluated using the Area Deprivation Index.
resultsElevated XO activity was significantly associated with dyspnea severity (β = 0.75, p < .001). Chemokines linked to T cell activation (e.g., CC motif ligand[CCL]-11, CXC motif ligand[CXCL]-8) correlated with HF symptoms and psychological distress, including anxiety and perceived stress. Higher neighborhood deprivation scores were associated with increased stress, sleep disturbance, and inflammatory biomarkers (e.g., interleukin[IL]-4, vascular cell adhesion molecule[VCAM]-1).
conclusionsThis study highlights the role of inflammation and neighborhood deprivation in HF symptomatology among Black adults. Targeting oxidative stress and inflammatory pathways, alongside addressing social determinants of health, may reduce symptom burden and improve outcomes in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.