Evidence map›Paper›PMID 40638893›Full record

ArticleChemistry & biodiversity2025

Efficacy of Essential Oil of Algrizea minor Sobral, Faria & Proença (Myrtaceae) in Combating Methicillin-resistant Staphylococcus aureus: Antibacterial and Virulence Modulation Studies Conducted In Vitro and In Vivo.

Amanda Vieira de Barros, Bruno Oliveira de Veras, Henrique Nelson Pereira Costa Júnior, Raudiney Frankilin Vasconcelos Mendes, Patryck Érmerson Monteiro Dos Santos, Jael Fernandes Tavares, Daniela Maria do Amaral Ferraz Navarro, Rafael Matos Ximenes, Patrícia Maria Guedes Paiva, Clovis Macedo Bezerra Filho and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Amanda Vieira de BarrosDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil.
Bruno Oliveira de VerasDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil.
Henrique Nelson Pereira Costa JúniorDepartment of Antibiotics, Federal University of Pernambuco, Recife, Brazil.
Raudiney Frankilin Vasconcelos MendesDepartment of Antibiotics, Federal University of Pernambuco, Recife, Brazil.
Patryck Érmerson Monteiro Dos SantosDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil.
Jael Fernandes TavaresDepartment of Fundamental Chemistry, Federal University of Pernambuco, Recife, Brazil.
Daniela Maria do Amaral Ferraz NavarroDepartment of Fundamental Chemistry, Federal University of Pernambuco, Recife, Brazil.
Rafael Matos XimenesDepartment of Antibiotics, Federal University of Pernambuco, Recife, Brazil.
Patrícia Maria Guedes PaivaDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil.
Clovis Macedo Bezerra FilhoSchool of Health and Life Sciences, Catholic University of Pernambuco, Recife, Brazil.
Josinaldo Alves da SilvaBiosciences Center, Federal University of Pernambuco, Recife, Brazil.
Márcia Vanusa da SilvaDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil.
João Paulo Martins de LimaCECAPE College, Juazeiro do Norte, Brazil.
Henrique Douglas Melo CoutinhoDepartment of Biological Chemistry, Regional University of Cariri, Crato, Brazil.ORCID https://orcid.org/0000-0002-6634-4207
Maria Betânia Melo de OliveiraDepartment of Biochemistry, Federal University of Pernambuco, Recife, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are difficult to treat due to its resistance profile and the scarcity of new antibiotics, necessitating alternative therapeutic strategies. This study explores the antibacterial, antivirulence, and in vivo effects of Algrizea minor essential oil (EOAM) against MRSA isolates. Chemical analysis identified β-pinene (38.73%) and α-pinene (11.79%) as the major constituents of EOAM. The oil exhibited synergistic effects when combined with amoxicillin and oxacillin, inhibiting biofilm formation and reducing S. aureus-induced hemolysis. Additionally, EOAM enhanced the efficacy of hydrogen peroxide (H₂O₂) against S. aureus. In vivo, EOAM significantly increased the survival of Galleria mellonella larvae infected with MRSA, reducing bacterial load and myelinization. These findings highlight the therapeutic potential of EOAM in treating MRSA infections by modulating bacterial resistance and virulence, suggesting their potential for application in clinical settings.

Indexed as

Anti-Bacterial AgentsMethicillin-Resistant Staphylococcus aureusOils, VolatileAnimalsBiofilmsHemolysisLarvaMicrobial Sensitivity TestsMothsStaphylococcal InfectionsVirulenceAnti-Bacterial AgentsOils, Volatileamoxicillinantibiotic resistance modulationGalleria mellonellanatural compoundsterpenes

Identifiers

PMID40638893
PMCPMC12629163

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.