Evidence map›Paper›PMID 40638878›Full record

ArticleJCO precision oncology2025

Prognostic Role of

James Lyon, Soravis Osataphan, Vaibhav Birda, Brian Russell, Charly Edmiston, Rodrigo Paredes, Ahmed Rattani, Mary Linton Peters

Abstract read
In one paragraph

Article in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  3. Review
  4. Article
  5. Genomics ofJCO precision oncology · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

James LyonDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0009-0008-2275-6067
Soravis OsataphanDivision of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-6503-4418
Vaibhav BirdaDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Brian RussellDivision of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-2462-2299
Charly EdmistonDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Rodrigo ParedesDepartment of Medicine, Beth Israel Mount Sinai, New York City, NY.ORCID 0000-0003-2886-9763
Ahmed RattaniDivision of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-1058-7314
Mary Linton PetersDivision of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0003-0905-7583

Funding

Harvard Clinical and Translational Science CenterUM1TR004408 · NCATS · HARVARD MEDICAL SCHOOL · PI Lindsey Robert Baden, Lee Marshall Nadler · 2023 to 2026
$43.3M
Tissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI SHIVDASANI, RAMESH A · 2007 to 2023
$33.2M
The dynamics and underlying mechanisms controlling cell size and canonical Wnt signalingR35GM145248 · NIGMS · HARVARD MEDICAL SCHOOL · PI MARC Wallace KIRSCHNER · 2022 to 2026
$3.9M
Cost Effectiveness of Germline Genetic Testing in Pancreatic CancerK08CA248473 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PETERS, MARY LINTON B · 2020 to 2024
$1.3M
NCATS NIH HHS UM1 TR004408NCI NIH HHS K08 CA248473NCI NIH HHS P50 CA127003NIGMS NIH HHS R35 GM145248
6 · The paper itself

Abstract

purposeMethylthioadenosine phosphorylase (

methodsThis is a single-center retrospective cohort study of patients with CCA from December 2017 to January 2024. Somatic genomics alterations were assessed using targeted next-generational sequencing with FoundationOne CDx. Patient demographics, tumor characteristics, treatment history, and overall survival (OS) were retrospectively collected. Genomics coalterations were assessed using the Fisher exact test. Multivariate Cox proportional hazards regression analysis was used to assess the relationship between

resultsAmong 94 CCA samples, 89 were successfully sequenced, uncovering 339 genomic alterations, with

conclusion

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaPurine-Nucleoside PhosphorylaseAdultAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective Studies5'-methylthioadenosine phosphorylasePurine-Nucleoside Phosphorylase

Identifiers

PMID40638878
PMCPMC12794466

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.