ArticleJournal of the American Chemical Society2025
Monofluoromethyl Radical Mediated Halogen-Atom Transfer.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Regio-, Stereo-, and Enantioselective C(spAngewandte Chemie (International ed. in English) · 2026Article
- Enabling Fluoroalkyl-Sulfonylalkylation and Fluoroalkyl-Halogenation of Alkenes and Alkynes via Photoredox Catalysis.Journal of the American Chemical Society · 2026Article
- Photochemical Fluoroalkylations with Fluorinated Gases Facilitated by a Robust Metal-Organic Framework.Journal of the American Chemical Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Halogen-atom transfer (XAT) is an effective method for generating carbon radicals from alkyl halides. While stannanes and silanes have shown potential, their toxicity and secondary reactivity necessitate the search for better alternatives. Recently, carbon-based α-amino alkyl radicals have emerged as possible substitutes; however, their generation under photochemical conditions requires the use of photocatalysts. In this work, we present a novel XAT method that eliminates the need for photocatalysts by utilizing the direct excitation of a monofluoroacetoxy ligand-containing hypervalent iodine(III) reagent. This approach allows nucleophilic monofluoromethyl radicals to efficiently form carbon radicals from activated alkyl halides. These radicals can subsequently functionalize unactivated alkenes through atom transfer radical addition (ATRA). Our mechanistic studies provide insights into the generation of monofluoromethyl radical and its unique reactivity. This work highlights the untapped potential of simple, single carbon atom-containing radicals for effective alkyl radical generation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.