Evidence map›Paper›PMID 40638800›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2025

Quantitative cardiovascular magnetic resonance myocardial perfusion can discriminate significant cardiac allograft vasculopathy: a multi-centre study.

R Jablonowski, H B Andersson, C Fogarasi, H Engblom, H Arheden, P Kellman, M Carlsson, M Melin, I H Löfman, J Nickander and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

R JablonowskiClinical Physiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.ORCID 0000-0001-9424-5663
H B AnderssonCardiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Entrégatan 7, 22242 Lund, Sweden.
C FogarasiDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
H EngblomClinical Physiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.ORCID 0000-0001-6424-5646
H ArhedenClinical Physiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Lund, Sweden.ORCID 0000-0002-6124-3159
P KellmanNational Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-9875-6070
M CarlssonDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
M MelinDepartment of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.
I H LöfmanDepartment of Medicine, Karolinska Institutet, Solna, Sweden.
J NickanderDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
O Ö BraunCardiology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, Entrégatan 7, 22242 Lund, Sweden.ORCID 0000-0003-3263-2718

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsCardiac allograft vasculopathy (CAV) is a significant complication that contributes to both morbidity and mortality after heart transplantation. The aim of this study was to (i) assess if quantitative cardiovascular magnetic resonance (CMR) myocardial perfusion could detect different stages of CAV and (ii) establish a myocardial perfusion reserve (MPR) cut-off for significant CAV. METHODS AND

resultsPatients with a heart transplant who had performed a clinical CMR scan and invasive angiography at two centres in Sweden were included in the study (n = 110). Quantitative short-axis perfusion maps were acquired using single-bolus gadolinium contrast, dual-sequence perfusion imaging at rest and during stress. Global myocardial perfusion (MP) was averaged across all segments at rest and stress and MPR was defined as the ratio between stress and rest MP. All invasive angiographies were reported according to the International Heart and Lung Transplantation CAV classification. Patients were classified as follows: 53% (58/110) as CAV0, 38% (42/110) as CAV1, and 9% (10/110) as CAV2-3. There was a gradual decrease of stress MP and MPR with increased CAV grade. The MPR could discriminate CAV2-3 with an area under the curve-receiver operating characteristic of 0.88, 95% confidence interval 0.78-0.98, and using a cut-off of 2.2, the sensitivity was 100%, specificity was 68%, and positive and negative predictive values were 21 and 100%.

conclusionIn this multi-centre retrospective study, MPR assessed by CMR could discriminate CAV2-3 with both high sensitivity and negative predictive value and a cut-off of MPR 2.2 is suggested.

Indexed as

Coronary Artery DiseaseHeart TransplantationMagnetic Resonance Imaging, CineMyocardial Perfusion ImagingAdultAllograftsContrast MediaCoronary AngiographyFemaleHumansMaleMiddle AgedRetrospective StudiesROC CurveSensitivity and SpecificitySeverity of Illness IndexContrast Mediacardiac allograft vasculopathy (CAV)heart transplantationmyocardial perfusionquantitative cardiovascular magnetic resonance (CMR)

Identifiers

PMID40638800
PMCPMC12481015

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