ArticleScience (New York, N.Y.)2025
Discrete spatiotemporal encoding of striatal dopamine transmission.
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Synapse-like specializations at dopamine release sites orchestrate efficient and precise neuromodulatory signaling.Science advances · 2026Article
- The Cellular and Synaptic Actions of Dopamine During Behavior.bioRxiv : the preprint server for biology · 2026Article
- Illuminating the Future of Catecholamine Detection.Journal of neurochemistry · 2026Review
- The Synaptic Vesicle Priming Protein Munc13 Mediates Evoked Somatodendritic Dopamine Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Optical insights into spatial precision and release heterogeneity of neuromodulatory transmission.iScience · 2026Article
- Spatiotemporally Distinct Dopamine Domains in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Impact of distinct neurotransmitter release modes on neuronal signaling.Molecular psychiatry · 2026Review
- The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.bioRxiv : the preprint server for biology · 2025Article
- Neurodegenerative Disease Movement Disorders and Dorsal Striatum-Mediated Imbalance of Habitual Motor Sequences.Molecular neurobiology · 2025Review
- Ventral striatal astrocytes contribute to reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons.Frontiers in cellular neuroscience · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Dopamine (DA) transmission critically regulates diverse, basal ganglia-dependent behaviors by activating distinct subtypes of G protein-coupled receptors. Spatially broad DA release has been extensively characterized, but how DA transmission affects striatal function at a subcellular scale remains poorly understood. Using 2P imaging and whole-cell electrophysiology, we defined the spatiotemporal properties of DA transmission onto striatal indirect pathway spiny projection neurons. Sparse activation of DA release sites evoked localized DA signals, producing spatially discrete, D2 receptor-mediated responses across dendrites. The spatiotemporal properties of DA receptor signaling differed between downstream intracellular pathways. We propose that membrane-delimited Gβγ signaling occurs in parallel to intracellular second messenger pathways, but on different spatial and temporal scales, providing a mechanism for precise decoding of DA signals by striatal neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.