Evidence map›Paper›PMID 40638673›Full record

ArticlePloS one2025

Contributing to a value-based health care framework for lung cancer patients in Switzerland - A methodological approach to merge routinely collected hospital data.

Michaela Carla Barbier, Katya Galactionova, Mark Lambiris, Leonel Oliveira, Florian Rüter, Dominik Glinz, Jessica Thürmer, Flurina Pletscher, Benjamin Kasenda, Tobias Finazzi and 5 more

Abstract read
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Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michaela Carla BarbierInstitute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-2682-537X
Katya GalactionovaInstitute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland.
Mark LambirisInstitute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-1337-1778
Leonel OliveiraQuality Management and Value-based Health Care, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0005-6837-7116
Florian RüterQuality Management and Value-based Health Care, University Hospital Basel, Basel, Switzerland.
Dominik GlinzRoche Pharma (Schweiz) AG, Basel, Switzerland.ORCID https://orcid.org/0000-0003-3509-8186
Jessica ThürmerRoche Pharma (Schweiz) AG, Basel, Switzerland.
Flurina PletscherRoche Pharma (Schweiz) AG, Basel, Switzerland.
Benjamin KasendaMedical Oncology, University and University Hospital Basel, Basel, Switzerland.
Tobias FinazziClinic of Radiotherapy and Radiation Oncology, University Hospital Basel, Basel, Switzerland.
David KönigMedical Oncology, University and University Hospital Basel, Basel, Switzerland.
Didier LardinoisDepartment of Thoracic Surgery, University Hospital Basel, Basel, Switzerland.
Larissa ConradMedical Controlling, Finance Department, University Hospital Basel, Basel, Switzerland.
Leonie MutzQuality Management and Value-based Health Care, University Hospital Basel, Basel, Switzerland.
Matthias SchwenkglenksInstitute of Pharmaceutical Medicine (ECPM), University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe concept of Value-Based Health Care (VBHC) seeks to maximise patient value by optimising health outcomes considering costs. However, necessary data are not readily available. In Switzerland, hospital accounting is disconnected from patient outcomes and treatment data. We demonstrate the feasibility of merging routine hospital data, including patient-reported outcome measures (PROMs), to implement core elements of VBHC in a real-world lung cancer centre.

methodsWe developed a merging approach using records from 208 newly diagnosed lung cancer patients treated at University Hospital Basel between June 2020 and November 2023. Maximum patient follow-up was 12-months. Clinician-reported outcome measure (CROM) and PROM data collection followed the International Consortium for Health Outcomes Measurement (Lung Cancer Set) standard. Cost data were extracted from Switzerland's standard hospital accounting system (REKOLE®). To illustrate analytical options offered by the merged data, we analysed partial correlations between costs and utility changes from baseline.

resultsThe merging approach successfully allocated costs to specific lung cancer treatments and separated costs for comorbidity care, enabling an initial presentation of cost distributions for different elements of care. Median total first-year hospital costs per lung cancer patient were CHF 77,834 (mean CHF 93,621). Immunotherapy incurred the highest median costs of CHF 45,394 (mean CHF 49,518), followed by surgery of CHF 41,665 (mean CHF 48,940). First-year costs for patients diagnosed with stage I tended to be lower than for later stages. A standard graphical tool was developed to track individual patient treatment, outcome, and cost over time.

conclusionsThis proof-of-concept analysis demonstrates the feasibility of a novel data merging approach as a foundation for VBHC implementation. While limited by sample size and follow-up duration, our method supports future treatment-cost-benefit models. It is reproducible and scalable across other conditions and hospitals, enabling the development of lung cancer treatments towards greater value and efficiency.

Indexed as

Lung NeoplasmsAgedAged, 80 and overCost-Benefit AnalysisFemaleHealth Care CostsHospitalsHumansMaleMiddle AgedPatient Reported Outcome MeasuresSwitzerlandValue-Based Health Care

Identifiers

PMID40638673
PMCPMC12244553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.