ArticleVeterinary medicine and science2025
Evaluating the Potential of Microdosing 1cp-LSD for the Treatment of Canine Anxiety: A One-Month Case Study.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Evaluation of 1cp-LSD for Enhancing Welfare in Shelter Dogs: A Randomized Blind Trial with Ethological Intervention.Veterinary sciences · 2026Article
- Understanding treatment expectations toward emerging therapies in veterinary medicine: the role of knowledge, attitudes, and beliefs toward psychedelic-assisted interventions.Frontiers in veterinary science · 2026Article
- Psychedelics as Novel Therapeutics for Chronic Pain in Veterinary Medicine: A Hypothesis-Driven Protocol Using Low-Dose 1-Cyclopropionyl-D-lysergic Acid Diethylamide (1cp-LSD) in Canine Osteoarthritis.Animals : an open access journal from MDPI · 2025Article
- Preliminary Findings on Low-Dose 1cp-LSD for Canine Anxiety: Exploring the Role of Owner Neuroticism and Psychopathology.Veterinary sciences · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This pilot study explored the potential of microdosing 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) to treat canine anxiety. A single-case study was conducted on a 13-year-old female dog with severe separation anxiety, who was treated with 5 µg of 1cp-LSD every 3 days for a month. Anxiety was assessed before, after, and 1 month following treatment using a validated questionnaire. The owner's attachment style was assessed using a validated scale. The dog's anxiety score significantly decreased from 29 (severe) to 14 (moderate) after treatment. A reduction in anxiety levels was observed, characterized by decreased destructive behaviour and shorter durations of vocalization. This improvement was sustained 1 month following treatment, although vocalization frequency increased. These findings suggest potential therapeutic efficacy of microdosing 1cp-LSD in managing canine anxiety; however, the absence of a control group makes it difficult to determine whether the observed effects are due to 1cp-LSD, owner bias, or natural variability in the dog's behaviour. Additional studies with blinded protocols and larger sample sizes are necessary to validate these findings and further explore the impact of owner attachment on canine anxiety.
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Registered trials
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