Evidence map›Paper›PMID 40638512›Full record

ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2025

Osteomyelitis and aortic arteritis with thrombosis as primary manifestations of severe paracoccidioidomycosis: a case report.

Amaro Nunes Duarte-Neto, Katia Cristina Dantas, Suzete Cleusa F Spina Lombardi, Roseli Santos de Freitas-Xavier, Adriana P Vicentini, Alfredo Mendroni Junior, Simon Claros Claros, Luiz Fernando Ferraz da Silva, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amaro Nunes Duarte-NetoUniversidade de São Paulo Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6659-7186
Katia Cristina DantasUniversidade de São Paulo Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-1346-9003
Suzete Cleusa F Spina LombardiFundação Pró-Sangue, Divisão de Pesquisa - Segurança Transfusional, São Paulo, São Paulo Brazil.ORCID http://orcid.org/0000-0002-4190-0238
Roseli Santos de Freitas-XavierUniversidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5811-5255
Adriana P VicentiniInstituto Adolfo Lutz, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-9321-0909
Alfredo Mendroni JuniorFundação Pró-Sangue, Divisão de Pesquisa - Segurança Transfusional, São Paulo, São Paulo Brazil.ORCID http://orcid.org/0000-0002-3090-4575
Simon Claros ClarosUniversidade de São Paulo Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.
Luiz Fernando Ferraz da SilvaUniversidade de São Paulo Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-0181-6357
Paulo Hilário Nascimento SaldivaUniversidade de São Paulo Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-2005-8253
Marisa DolhnikoffUniversidade de São Paulo Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-9073-9989
Marielton Dos Passos CunhaUniversidade Estadual de Campinas, Instituto de Biologia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Campinas, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-2102-631X
Thais MauadUniversidade de São Paulo Faculdade de Medicina, Departamento de Patologia, São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-3354-1466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paracoccidioidomycosis (PCM) configures a deep mycosis caused by Paracoccidioides spp., a neglected tropical disease. We describe a fatal case of PCM that manifested itself as osteomyelitis with thrombosis in the iliac artery in a man with frequent contact with an endemic region in Sao Paulo, Brazil. A 67-year-old man living in an endemic area presented with osteomyelitis of the femur and iliac artery thrombosis on admission to the hospital. Computed tomography of the chest showed multiple cavitated pulmonary nodules. The patient rapidly progressed to irreversible respiratory failure. The autopsy showed disseminated PCM and iliac artery thrombosis. Laboratory investigation confirmed P. brasiliensis infection with a strain identified in Sao Paulo as P. brasiliensis complex by phylogenetic analysis. Atypical PCM remains a diagnostic challenge. Increased awareness of the sites of infection and its clinical presentations will improve patient management.

Indexed as

ArteritisIliac ArteryOsteomyelitisParacoccidioidomycosisThrombosisAgedFatal OutcomeHumansMaleTomography, X-Ray Computed

Identifiers

PMID40638512
PMCPMC12233582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.