ArticleJournal of applied oral science : revista FOB2025
Orofacial myofunctional and anthropometric characteristics of children with and without microcephaly: a case-control study.
Article in Journal of applied oral science : revista FOB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to describe and compare morphofunctional orofacial aspects between subjects with and without Zika virus-related microcephaly. METHODOLOGY: This was a descriptive, cross-sectional, case-control study with both qualitative and quantitative components. All subjects were born between 2015 and 2016, during the Zika virus outbreak in the Northeast region of Brazil. A total of 48 children were included: 24 with Zika-related microcephaly (MG) and 24 without the condition (CG). We performed the Preliminary Expanded Protocol of Orofacial Myofunctional Evaluation with Scores (OMES-E) for all subjects. Orofacial anthropometric measurements were obtained from 36 of the 48 participants, including 18 from the MG and 18 from the CG.
resultsWe found lower swallowing efficiency scores in children with microcephaly aged 13-18 months. Significant differences (p<.001) were found between the MG and CG for scores related to the face, cheeks, and total stomatognathic functions. When stratified by age group, differences (p<.001) were found in total scores between MG and CG subjects in the age groups up to 24 months. We found lower scores in the 13-18-month group with microcephaly for swallowing efficiency: 1.3 (SD: .8) versus 5.3 (SD: 1.2); and in the 19-24-month group; for bite: 1 (SD: 0) and 3.9 (SD: .3), and 1.9 (SD: 2.7) and 9.5 (SD: .9); in addition to facial changes: 9.8 (SD: 1.2) and 11.8 (SD: .6). Differences were found in anthropometric orofacial measurements for the upper third of the face (d=-1.215, p<.001) (MG<CG); proportion between the upper third/middle third (d=.463, p=.018) (MG<CG); and upper lip and philtrum (MG>CG) (d=-.679, p<.001).
conclusionSubjects with microcephaly had altered orofacial myofunction, especially related to swallowing and chewing difficulties in early ages.
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