Evidence map›Paper›PMID 40638390›Full record

ArticleCell reports2025

Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense.

Nina Salinger Prasanphanich, Giulia Protti, Monica Cappelletti, Feiyang Ma, Neema Pithia, Angel Dasenbrock, Jerzy Stanek, Claire A Chougnet, Suhas G Kallapur, Matteo Pellegrini and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nina Salinger PrasanphanichDivision of Infectious Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Giulia ProttiDepartment of Molecular, Cell and Developmental Biology Medicine at the University of California, Los Angeles, 610 Charles E. Young Dr. S, Los Angeles, CA 90095, USA; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.
Monica CappellettiDepartment of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, Los Angeles, CA 90095, USA.
Feiyang MaDepartment of Molecular, Cell and Developmental Biology Medicine at the University of California, Los Angeles, 610 Charles E. Young Dr. S, Los Angeles, CA 90095, USA; Institute for Quantitative and Computational Biosciences - Collaboratory at the University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Cell and Developmental Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Neema PithiaDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
Angel DasenbrockDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Jerzy StanekDivision of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Claire A ChougnetDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Suhas G KallapurDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology Medicine at the University of California, Los Angeles, 610 Charles E. Young Dr. S, Los Angeles, CA 90095, USA; Institute for Quantitative and Computational Biosciences - Collaboratory at the University of California, Los Angeles, Los Angeles, CA 90095, USA.
Tamara TilburgsDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address: tamara.tilburgs@cchmc.org.
Pietro PresicceDivisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: ppresicce@mednet.ucla.edu.

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Transcriptomics and biomarkers of fetal neuroinflammationR01HD098389 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KALLAPUR, SUHAS · 2019 to 2023
$3.8M
Prenatal inflammatory exposures and neonatal immune developmentU01ES029234 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CHOUGNET, CLAIRE A. · 2017 to 2021
$2.7M
Drug repurposing of a novel synthetic progestin for the prevention of preterm labor and fetal inflammationR01HD114495 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUHAS KALLAPUR, Sam Antonio MESIANO · 2024 to 2026
$2.0M
Vaccinology Training ProgramT32AI165396 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Robert Wilson Frenck, PAUL W. SPEARMAN · 2022 to 2026
$1.4M
The role of HLA-C in chronic chorioamnionitisR01HD116852 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Tamara Tilburgs · 2025 to 2026
$1.2M
ZE5 Analytical CytometerS10OD025045 · OD · CINCINNATI CHILDRENS HOSP MED CTR · PI THORNTON, SHERRY L · 2018 to 2018
$359k
NIAID NIH HHS T32 AI165396NICHD NIH HHS K12 HD000850NICHD NIH HHS R01 HD098389NICHD NIH HHS R01 HD114495NICHD NIH HHS R01 HD116852NIEHS NIH HHS U01 ES029234NIH HHS S10 OD025045
6 · The paper itself

Abstract

Decidual natural killer cells (dNKs) are key immune effector cells at the maternal-fetal interface. dNKs utilize the antimicrobial peptide granulysin (GNLY) to kill bacteria without killing infected trophoblasts. Since rodents lack the GNLY gene, the in vivo biology of GNLY expression by dNKs and their role during intra-uterine infection (IUI) is not well understood. Here, we defined dNK GNLY expression in placental membranes in a rhesus macaque model of IUI and compared it with human acute chorioamnionitis (ACA). GNLY-high dNKs of both species shared conserved transcriptional and protein signatures of antimicrobial defense and immunoregulation. Moreover, GNLY-high dNKs responded to inflammation and infection by increasing their cytotoxic, cytokine, and inflammatory signatures. Thus, high GNLY expression defines a unique dNK type with active roles in immune defense. Defining the regulatory networks of GNLY expression by dNKs and their unique mechanisms of infection control will generate therapeutic opportunities to enhance immunity and reduce IUI-related pregnancy complications.

Indexed as

Antigens, Differentiation, T-LymphocyteDeciduaKiller Cells, NaturalAnimalsCytokinesFemaleHumansMacaca mulattaPregnancyAntigens, Differentiation, T-LymphocyteCytokinesGNLY protein, humanchorioamnionitisCP: ImmunologycytotoxicitydeciduadNKgranulysininnate immunityIntra-uterine infectionnatural killer cellsplacentapregnancy

Identifiers

PMID40638390
PMCPMC12329683

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.