Evidence map›Paper›PMID 40638090›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Glycogen supports glycolytic plasticity in neurons.

Milind Singh, Aaron D Wolfe, Anjali A Vishwanath, Anastasia Tsives, Ian J Gonzalez, Sarah E Emerson, Richard Goodman, Daniel Colón-Ramos

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Inorganic phosphate and the rapid mobilization of metabolic energy in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Glycolytic Specialization Shapes Neuronal Physiology and FunctionbioRxiv : the preprint server for biology · 2026
    Article
  8. Neuromodulatory control of energy reserves in dopaminergic neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milind Singh *Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
Aaron D Wolfe *Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-4926-5064
Anjali A VishwanathDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
Anastasia TsivesDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
Ian J GonzalezDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
Sarah E EmersonDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
Richard GoodmanDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
Daniel Colón-RamosDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Examination of the cell biology of the synapse and behaviorR35NS132156 · NINDS · YALE UNIVERSITY · PI DANIEL A COLON-RAMOS · 2023 to 2026
$4.6M
NIH HHS P40 OD010440NINDS NIH HHS R35 NS132156
6 · The paper itself

Abstract

Glycogen is the largest energy reserve in the brain, but the specific role of glycogen in supporting neuronal energy metabolism in vivo is not well understood. We established a system in

Indexed as

GlycogenGlycolysisNeuronal PlasticityNeuronsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEnergy MetabolismGlycogen PhosphorylaseMitochondriaSynaptic VesiclesCaenorhabditis elegans ProteinsGlycogenGlycogen PhosphorylaseC. elegansglycogen utilizationglycolytic biosensorglycolytic plasticityneuronal metabolism

Identifiers

PMID40638090
PMCPMC12280961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.