Evidence map›Paper›PMID 40638084›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism.

Conor J Crawford, Charles W E Tomlinson, Christian Gunawan, Zongjia Chen, Dominic P Byrne, Cosette Darby, Martina L G Conti, Tony Larson, Ana S Luis, Stefano Elli and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Conor J Crawford *Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam 14476, Germany.
Charles W E Tomlinson *Department of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0002-1845-6028
Christian GunawanSchool of Chemistry and Bio21, Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.
Zongjia ChenSchool of Chemistry and Bio21, Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.ORCID 0000-0002-8829-7042
Dominic P ByrneDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom.ORCID 0000-0001-5197-345X
Cosette DarbyBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.
Martina L G ContiDepartment of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0003-1343-1291
Tony LarsonDepartment of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0003-1337-3482
Ana S LuisDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg 405 30, Sweden.
Stefano ElliIstituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Milano 20133, Italy.ORCID 0000-0003-0686-2480
Edwin A YatesDepartment of Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom.ORCID 0000-0001-9365-5433
David N BolamBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.ORCID 0000-0003-0314-3122
Sjoerd van der PostDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg 405 30, Sweden.ORCID 0000-0002-7965-5311
Spencer J WilliamsSchool of Chemistry and Bio21, Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.ORCID 0000-0001-6341-4364
Alan CartmellDepartment of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0002-5512-249X

Funding

Academy of Medical Royal Colleges (AoMRC) SBF005\1065 163470Wellcome TrustWellcome Trust (WT) 225897/Z/22/Z
6 · The paper itself

Abstract

Excessive degradation of the colonic mucin layer by

Indexed as

BacteroidesColonGastrointestinal MicrobiomeSulfatasesSulfonic AcidsAnimalsHumansInflammatory Bowel DiseasesMiceSulfatasesSulfonic Acidsarylsulfamatescomplex glycansdrug discoverygut microbiotasulfatases

Identifiers

PMID40638084
PMCPMC12280919

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.