ArticleOphthalmology and therapy2025
Alterations in Peripheral Refraction are Most Significant Just Before the Onset of Myopia: Evidence from Multispectral Refraction Topography.
Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Spectacle lenses for control of myopia progression in children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
- Peripheral retinal defocus in children and adolescents with different refractive statuses and its relationship with refractive parameters.BMC ophthalmology · 2026Article
- Quantitative assessment of relative peripheral refraction in children with different refractive statuses and its associations with ocular biometry.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionThis study aims to explore the characteristics of retinal defocus values (RDVs) during refractive development of Chinese children.
methodsIn this cross-sectional study, 2125 children (2125 right eyes) aged 4-15 years were included and divided into several groups according to spherical equivalent (SE) or axial length (AL). Ocular biological parameters including AL, central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and corneal curvature were detected, and multispectral refractive tomography (MRT) was used to measure total retinal defocus values (TRDV), RDVs of 0°-15°/15°-30°/30°-45° concentric annulus area (RDV-15/30/45), RDVs of the superior, nasal, inferior and temporal fan-shaped region (RDV-S/N/I/T).
resultsCCT and ACD increased while LT decreased with myopia progression. As diopter descended, almost all RDVs gradually inclined to hyperopic defocus; however, the superior retina demonstrated consistent myopic defocus across different dioptric states. RDV-45 and RDV-T changed most obviously among RDV-15/30/45 and RDV-S/N/I/T, respectively. Importantly, hyperopic shift of RDVs was most pronounced between the emmetropia and low myopia group, and also when AL was approximately 23 mm. Additionally, difference between superior and inferior RDVs also peaks in early myopia.
conclusionsThe rapid changes and longitudinal inequality of RDVs are most significant just before 23 mm of AL, this condition may have important predictive value for the occurrence of myopia. Additionally, defocus of the temporal retina showed the greatest variation in dioptric development, suggesting that nasal visual information may affect refractive outcomes.
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