Evidence map›Paper›PMID 40637979›Full record

ReviewSub-cellular biochemistry2025

Physiological Functions of Urea Transporters.

Zhiwei Qiu, Tao Jiang, Guangying Shao, Baoxue Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhiwei QiuInstitute of Clinical Pharmacology, Peking University First Hospital, Beijing, China. 11067@pkufh.com.
Tao JiangCollege of Basic Medicine, Beihua University, Jilin, China.
Guangying ShaoDepartment of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Baoxue YangDepartment of Pharmacology, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing, China. baoxue@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urea transporters (UTs) are a group of membrane channel proteins that specifically facilitate the permeation of urea, which play an essential role in urea reabsorption and water conservation. There are 4 isoforms, UT-A1, UT-A2, UT-A3, UT-B, that are expressed in the kidney to maintain the urea recycle and establish the urea concentration gradient in the medulla, which is essential for the urinary concentration capacity of the kidney. Outside the kidney, widely distributed UT-B and some UT-A isoforms directly participate in regulating signaling transduction and determining cell fate by regulating osmotic pressure, arginine metabolism, and protein carbamylation in various systems. In recent years, studies on different UT knockout mouse models revealed multiple physiological roles of UTs. This chapter summarizes the physiological functions of UTs, including the blood system, urinary system, nervous system, circulatory system, digestive system, auditory system, visual system, reproductive system, and skeletal system.

Indexed as

Membrane Transport ProteinsUreaAnimalsHumansKidneyMiceMice, KnockoutSignal TransductionUrea TransportersMembrane Transport ProteinsUreaUrea TransportersArginine metabolismOsmotic pressureProtein carbamylationUrea transporterUrine concentration

Identifiers

PMID40637979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.