Evidence map›Paper›PMID 40637978›Full record

ReviewSub-cellular biochemistry2025

Transport Characteristics of Urea Transporters.

Zhizhen Huang, Baoxue Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhizhen HuangState Key Laboratory of Vascular Homeostasis and Remodeling, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.
Baoxue YangState Key Laboratory of Vascular Homeostasis and Remodeling, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China. baoxue@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid urea permeation mediated by urea transporters (UTs) is crucial for maintaining normal physiological processes in organisms. UTs not only facilitate urea transport but also water transport, further underscoring their role in maintaining fluid balance. Advances in structural biology have led to the elucidation of high-resolution three-dimensional structures of various UTs, offering critical insights into the molecular mechanisms underlying their efficiency in transporting urea and water. UT-B displays high permeability to urea analogs, which can competitively inhibit urea permeation by obstructing the channel. However, whether UT-A is capable of transporting urea analogs remains contentious. Additionally, further investigation is required to determine if UTs can facilitate ammonia transport. Urea permeability (P

Indexed as

Membrane Transport ProteinsUreaAnimalsBiological TransportErythrocytesHumansUrea TransportersMembrane Transport ProteinsUreaUrea TransportersAmmoniaSpeciesUrea analoguesUrea transportWater transport

Identifiers

PMID40637978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.