Evidence map›Paper›PMID 40637974›Full record

ReviewSub-cellular biochemistry2025

Genes and Evolution of Urea Transporters.

Yi Ying, Bo Kan, Baoxue Yang, Jeff M Sands

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi YingState Key Laboratory of Vascular Homeostasis and Remodeling, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.
Bo KanDepartment of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, China.
Baoxue YangState Key Laboratory of Vascular Homeostasis and Remodeling, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China. baoxue@bjmu.edu.cn.
Jeff M SandsRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. jsands@emory.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urea transporters (UTs) are a group of membrane channel proteins that specifically facilitate the permeation of urea, from bacteria to mammals, playing an essential role in urea reabsorption and water conservation. In mammals, there are two subfamilies of UT: the UT-A group originally isolated from the kidney inner medulla, and UT-B originally isolated from erythrocytes. The human UT-B gene (Slc14a1) arises from a single locus located on chromosome 18q12.1-q21.1, which is close to the UT-A gene (Slc14a2). The human Slc14a1 gene includes 11 exons, with the coding region extending from exon 4 to exon 11, and is approximately 30 kb in length. The rat Slc14a2 gene is very large, containing 24 exons, approximately 300 kb in length, and encodes 6 different isoforms. The Slc14a2 gene has two promoter elements: promoter I, located upstream of exon 1, drives the transcription of UT-A1, UT-A1b, UT-A3, UT-A3b, and UT-A4; promoter II, located within intron 12, drives the transcription of UT-A2 and UT-A2b. This chapter will summarize the evolution and genetic characteristics of UTs.

Indexed as

Evolution, MolecularMembrane Transport ProteinsUreaAnimalsHumansPromoter Regions, GeneticRatsUrea TransportersMembrane Transport ProteinsUreaUrea TransportersErythrocytesKidneyUreaUrea transporterVasopressin

Identifiers

PMID40637974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.